Local treatment of hand-foot syndrome with uridine/thymidine: In vitro appraisal on a human keratinocyte cell line HaCaT

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12943" target="_blank" >RIV/00216208:11110/12:12943 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/12:43906417 RIV/00216305:26620/12:PU103211 RIV/00064165:_____/12:12943

Výsledek na webu

<a href="http://dx.doi.org/10.1100/2012/421325" target="_blank" >http://dx.doi.org/10.1100/2012/421325</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Local treatment of hand-foot syndrome with uridine/thymidine: In vitro appraisal on a human keratinocyte cell line HaCaT

Popis výsledku v původním jazyce

5-fluorouracil (5-FU) is one of the most commonly used antineoplastic drugs in the anticancer therapy. The hand-foot (HF) syndrome (palmar-plantar erythrodysesthesia) is an adverse effect frequently related to long-term i.v. administration of 5-FU or itsorally applicable prodrug capecitabine. Its severity can even lead to interruption of the otherwise effective anticancer therapy. Tentative practice in some clinics has shown that topical application of 10% uridine ointment is beneficial for calming down the HF syndrome. This study is focused on verifying the alleged protective activity of uridine in the in vitro model of cultured human keratinocyte cell line HaCaT. We also tested the protective effects of thymidine alone or uridine-thymidine combination. The cellular viability time progression was measured in order to evaluate the effect of protective agents by three different types of cytopathogenicity tests-NTCA test (non-destructive test of cellular activity), modified MTT test and

Název v anglickém jazyce

Local treatment of hand-foot syndrome with uridine/thymidine: In vitro appraisal on a human keratinocyte cell line HaCaT

Popis výsledku anglicky

5-fluorouracil (5-FU) is one of the most commonly used antineoplastic drugs in the anticancer therapy. The hand-foot (HF) syndrome (palmar-plantar erythrodysesthesia) is an adverse effect frequently related to long-term i.v. administration of 5-FU or itsorally applicable prodrug capecitabine. Its severity can even lead to interruption of the otherwise effective anticancer therapy. Tentative practice in some clinics has shown that topical application of 10% uridine ointment is beneficial for calming down the HF syndrome. This study is focused on verifying the alleged protective activity of uridine in the in vitro model of cultured human keratinocyte cell line HaCaT. We also tested the protective effects of thymidine alone or uridine-thymidine combination. The cellular viability time progression was measured in order to evaluate the effect of protective agents by three different types of cytopathogenicity tests-NTCA test (non-destructive test of cellular activity), modified MTT test and

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/NS9786" target="_blank" >NS9786: Intracelulární účinky uridinu v léčbě palmární-plantární erythrodyesthesie po kontinuální terapii fluoropyrimidiny - studie in vitro</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

The Scientific World Journal

ISSN

1537-744X

e-ISSN

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Svazek periodika

Neuveden

Číslo periodika v rámci svazku

Article Number: 421325

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

1-6

Kód UT WoS článku

000307735200001

EID výsledku v databázi Scopus

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