Dopamine 2 receptor expression in various pathological types of clinically non-functioning pituitary adenomas

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A8785" target="_blank" >RIV/00216208:11110/12:8785 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61383082:_____/12:#0000103 RIV/00216208:11150/12:10125041 RIV/00179906:_____/12:10125041 RIV/00064165:_____/12:8785

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s11102-011-0316-1" target="_blank" >http://dx.doi.org/10.1007/s11102-011-0316-1</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Dopamine 2 receptor expression in various pathological types of clinically non-functioning pituitary adenomas

Popis výsledku v původním jazyce

Clinically non-functioning pituitary adenomas account for about one-third of pituitary tumors. The majority of them are pathologically classified as gonadotropinomas or null-cell adenomas without hormonal expression. The rest represent silent corticotroph adenomas and plurihormonal tumors. Conservative therapy with dopamine agonists is effective in some cases only depending on the expression of dopamine 2 receptors (D2R). The aim of this study was to quantitatively estimate D2R expression in clinicallynon-functioning pituitary adenomas and correlate the results with adenoma type according to pathological classification. Out of the 87 adenomas investigated, 63 expressed gonadotropins, 7 were silent corticotroph adenomas, 7 were plurihormonal tumors, and only 6 did not express any pituitary hormone on immunohistochemical investigation.

Název v anglickém jazyce

Dopamine 2 receptor expression in various pathological types of clinically non-functioning pituitary adenomas

Popis výsledku anglicky

Clinically non-functioning pituitary adenomas account for about one-third of pituitary tumors. The majority of them are pathologically classified as gonadotropinomas or null-cell adenomas without hormonal expression. The rest represent silent corticotroph adenomas and plurihormonal tumors. Conservative therapy with dopamine agonists is effective in some cases only depending on the expression of dopamine 2 receptors (D2R). The aim of this study was to quantitatively estimate D2R expression in clinicallynon-functioning pituitary adenomas and correlate the results with adenoma type according to pathological classification. Out of the 87 adenomas investigated, 63 expressed gonadotropins, 7 were silent corticotroph adenomas, 7 were plurihormonal tumors, and only 6 did not express any pituitary hormone on immunohistochemical investigation.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/NT11344" target="_blank" >NT11344: Kvantitativní analýza somatostatinových receptorů v adenomech hypofýzy.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pituitary

ISSN

1386-341X

e-ISSN

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Svazek periodika

15

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

222-226

Kód UT WoS článku

000304405400016

EID výsledku v databázi Scopus

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