Changes in levels of matrix metalloproteinase-2 and-9, pregnancy-associated plasma protein-A in patients with various nephropathies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10173656" target="_blank" >RIV/00216208:11110/13:10173656 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21230/13:00206203 RIV/00064165:_____/13:10173656

Výsledek na webu

<a href="http://dx.doi.org/10.5301/jn.5000136" target="_blank" >http://dx.doi.org/10.5301/jn.5000136</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5301/jn.5000136" target="_blank" >10.5301/jn.5000136</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Changes in levels of matrix metalloproteinase-2 and-9, pregnancy-associated plasma protein-A in patients with various nephropathies

Popis výsledku v původním jazyce

Background: Specific changes and imbalanced concentrations of matrix metalloproteinases (MMPs) and pregnancy-associated plasma protein-A (PAPP-A) may reflect the pathophysiology of various nephropathies (GN). We compared MMP-2, MMP-9 and PAPP-A levels inpatients with GN, with those found in healthy controls. Methods: We studied 45 controls and 128 patients with GN, defined by kidney biopsy: IgA nephropathy (IgAN, n=33), membranous glomerulonephritis (MN, n=23), minimal change nephrotic syndrome (MCNS,n=7), focal segmental glomerular sclerosis (FSGS, n=11), lupus nephritis (LN, n=22) and ANCA-associated glomerulonephritis (AAV, n=32). MMP-2 and MMP-9 levels were assessed using enzyme-linked immunosorbent assay; PAPP-A levels were determined with time-resolved amplified cryptate emission, and routine biochemical parameters were measured. Results: Compared with controls, IgAN patients exhibited a significant decrease in levels of MMP-2 contrasted with increased MMP-9 and unchanged PAPP-

Název v anglickém jazyce

Changes in levels of matrix metalloproteinase-2 and-9, pregnancy-associated plasma protein-A in patients with various nephropathies

Popis výsledku anglicky

Background: Specific changes and imbalanced concentrations of matrix metalloproteinases (MMPs) and pregnancy-associated plasma protein-A (PAPP-A) may reflect the pathophysiology of various nephropathies (GN). We compared MMP-2, MMP-9 and PAPP-A levels inpatients with GN, with those found in healthy controls. Methods: We studied 45 controls and 128 patients with GN, defined by kidney biopsy: IgA nephropathy (IgAN, n=33), membranous glomerulonephritis (MN, n=23), minimal change nephrotic syndrome (MCNS,n=7), focal segmental glomerular sclerosis (FSGS, n=11), lupus nephritis (LN, n=22) and ANCA-associated glomerulonephritis (AAV, n=32). MMP-2 and MMP-9 levels were assessed using enzyme-linked immunosorbent assay; PAPP-A levels were determined with time-resolved amplified cryptate emission, and routine biochemical parameters were measured. Results: Compared with controls, IgAN patients exhibited a significant decrease in levels of MMP-2 contrasted with increased MMP-9 and unchanged PAPP-

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Nephrology

ISSN

1121-8428

e-ISSN

—

Svazek periodika

26

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

502-509

Kód UT WoS článku

000322053900012

EID výsledku v databázi Scopus

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