Loss of adhesion/growth-regulatory galectin-9 from squamous cell epithelium in head and neck carcinomas

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10173743" target="_blank" >RIV/00216208:11110/13:10173743 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/13:10173743 RIV/00064203:_____/13:10173743 RIV/00023736:_____/13:00009659 RIV/00064165:_____/13:10173743

Výsledek na webu

<a href="http://dx.doi.org/10.1111/j.1600-0714.2012.01185.x" target="_blank" >http://dx.doi.org/10.1111/j.1600-0714.2012.01185.x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/j.1600-0714.2012.01185.x" target="_blank" >10.1111/j.1600-0714.2012.01185.x</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Loss of adhesion/growth-regulatory galectin-9 from squamous cell epithelium in head and neck carcinomas

Popis výsledku v původním jazyce

Galectins are potent effectors of cell adhesion and growth regulation. Their expression as comples network necessitates systematic study of each member of this family. Toward this aim, we here focus on the tandem-repeat-type galectin-9. Its presence is monitored in normal squamous epithelium of the head and neck, the surgical margin, and four types of squamous cell carcinoma. Lectin presence was detected in cells of the basal layer of the epithelium. All galectin-9-negative epithelia showed aberrant positivity for keratins 14 and 19. The surgical margin presented either a normal pattern of galectin-9 and keratin presence or a mosaic-like presence/absence of galectin-9 and aberrant expression of both keratins 14 and 19. All studied specimens of squamouscell carcinoma were negative for galectin-9. When biotinylated galectin-9, or its N-terminal domain, was tested, no significant tissue reactivity for both probes was observed. Neuraminidase treatment generated reactivity to the N-domain.

Název v anglickém jazyce

Loss of adhesion/growth-regulatory galectin-9 from squamous cell epithelium in head and neck carcinomas

Popis výsledku anglicky

Galectins are potent effectors of cell adhesion and growth regulation. Their expression as comples network necessitates systematic study of each member of this family. Toward this aim, we here focus on the tandem-repeat-type galectin-9. Its presence is monitored in normal squamous epithelium of the head and neck, the surgical margin, and four types of squamous cell carcinoma. Lectin presence was detected in cells of the basal layer of the epithelium. All galectin-9-negative epithelia showed aberrant positivity for keratins 14 and 19. The surgical margin presented either a normal pattern of galectin-9 and keratin presence or a mosaic-like presence/absence of galectin-9 and aberrant expression of both keratins 14 and 19. All studied specimens of squamouscell carcinoma were negative for galectin-9. When biotinylated galectin-9, or its N-terminal domain, was tested, no significant tissue reactivity for both probes was observed. Neuraminidase treatment generated reactivity to the N-domain.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Oral Pathology and Medicine

ISSN

0904-2512

e-ISSN

—

Svazek periodika

42

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

166-173

Kód UT WoS článku

000314471200008

EID výsledku v databázi Scopus

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