Context-dependent multifunctionality of galectin-1: a challenge for defining the lectin as therapeutic target

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10174139" target="_blank" >RIV/00216208:11110/13:10174139 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1517/14728222.2013.750651" target="_blank" >http://dx.doi.org/10.1517/14728222.2013.750651</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1517/14728222.2013.750651" target="_blank" >10.1517/14728222.2013.750651</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Context-dependent multifunctionality of galectin-1: a challenge for defining the lectin as therapeutic target

Popis výsledku v původním jazyce

Introduction: One route of translating the information encoded in the glycan chains of cellular glycoconjugates into physiological effects is via receptor (lectin) binding. A family of endogenous lectins, sharing folding, a distinct sequence signature and affinity for beta-galactosides (thus termed galectins), does so effectively in a context-dependent manner. Areas covered: An overview is given on the multifunctional nature of galectins, with emphasis on galectin-1. The broad range of functions includes vital processes such as adhesion via glycan bridging, glycoconjugate transport or triggering signaling relevant, for example, for growth regulation. Besides distinct glycoconjugates, this lectin can also interact with certain proteins so that it can target counterreceptors at all sites of location, that is, in the cytoplasm and/or nucleus, at both sides of the membrane or extracellularly. Approaches to strategically exploit galectin activities with therapeutic intentions are outlined.

Název v anglickém jazyce

Context-dependent multifunctionality of galectin-1: a challenge for defining the lectin as therapeutic target

Popis výsledku anglicky

Introduction: One route of translating the information encoded in the glycan chains of cellular glycoconjugates into physiological effects is via receptor (lectin) binding. A family of endogenous lectins, sharing folding, a distinct sequence signature and affinity for beta-galactosides (thus termed galectins), does so effectively in a context-dependent manner. Areas covered: An overview is given on the multifunctional nature of galectins, with emphasis on galectin-1. The broad range of functions includes vital processes such as adhesion via glycan bridging, glycoconjugate transport or triggering signaling relevant, for example, for growth regulation. Besides distinct glycoconjugates, this lectin can also interact with certain proteins so that it can target counterreceptors at all sites of location, that is, in the cytoplasm and/or nucleus, at both sides of the membrane or extracellularly. Approaches to strategically exploit galectin activities with therapeutic intentions are outlined.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Expert Opinion on Therapeutic Targets

ISSN

1472-8222

e-ISSN

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Svazek periodika

17

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

379-392

Kód UT WoS článku

000316127600005

EID výsledku v databázi Scopus

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