Cultivation-dependent plasticity of melanoma phenotype

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10188864" target="_blank" >RIV/00216208:11110/13:10188864 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/13:10188864 RIV/00216224:14110/13:00069858

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s13277-013-0905-x" target="_blank" >http://dx.doi.org/10.1007/s13277-013-0905-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s13277-013-0905-x" target="_blank" >10.1007/s13277-013-0905-x</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cultivation-dependent plasticity of melanoma phenotype

Popis výsledku v původním jazyce

Malignant melanoma is a highly aggressive tumor with increasing incidence and high mortality. The importance of immunohistochemistry in diagnosis of the primary tumor and in early identification of metastases in lymphatic nodes is enormous; however melanoma phenotype is frequently variable and thus several markers must be employed simultaneously. The purposes of this study are to describe changes of phenotype of malignant melanoma in vitro and in vivo and to investigate whether changes of environmentalfactors mimicking natural conditions affect the phenotype of melanoma cells and can revert the typical in vitro loss of diagnostic markers. The influence of microenvironment was studied by means of immunocytochemistry on co-cultures of melanoma cells with melanoma-associated fibroblast and/or in conditioned media. The markers typical for melanoma (HMB45, Melan-A, Tyrosinase) were lost in malignant cells isolated from malignant effusion; however, tumor metastases shared identical phenotyp

Název v anglickém jazyce

Cultivation-dependent plasticity of melanoma phenotype

Popis výsledku anglicky

Malignant melanoma is a highly aggressive tumor with increasing incidence and high mortality. The importance of immunohistochemistry in diagnosis of the primary tumor and in early identification of metastases in lymphatic nodes is enormous; however melanoma phenotype is frequently variable and thus several markers must be employed simultaneously. The purposes of this study are to describe changes of phenotype of malignant melanoma in vitro and in vivo and to investigate whether changes of environmentalfactors mimicking natural conditions affect the phenotype of melanoma cells and can revert the typical in vitro loss of diagnostic markers. The influence of microenvironment was studied by means of immunocytochemistry on co-cultures of melanoma cells with melanoma-associated fibroblast and/or in conditioned media. The markers typical for melanoma (HMB45, Melan-A, Tyrosinase) were lost in malignant cells isolated from malignant effusion; however, tumor metastases shared identical phenotyp

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP304%2F12%2F1333" target="_blank" >GAP304/12/1333: Mezibuněčné interakce v maligním melanomu - experimentální studie</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Tumor Biology

ISSN

1010-4283

e-ISSN

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Svazek periodika

34

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

11

Strana od-do

3345-3355

Kód UT WoS článku

000328292100010

EID výsledku v databázi Scopus

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