Human Papillomavirus Infections and Upper Aero-Digestive Tract Cancers: The ARCAGE Study
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10188970" target="_blank" >RIV/00216208:11110/13:10188970 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1093/jnci/djt053" target="_blank" >http://dx.doi.org/10.1093/jnci/djt053</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/jnci/djt053" target="_blank" >10.1093/jnci/djt053</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Human Papillomavirus Infections and Upper Aero-Digestive Tract Cancers: The ARCAGE Study
Popis výsledku v původním jazyce
Human papillomavirus (HPV) is causally implicated in a subset of cancers of the upper aero-digestive tract (UADT). Associations between type-specific HPV antibodies were examined among 1496 UADT cancer case subjects and 1425 control subjects by estimating odds ratios (ORs) in logistic regression analyses adjusted for potential confounders. The agreement between serology and tumor markers of HPV infection, including presence of HPV DNA and p16 expression, were examined in a subset of tumors. HPV16 L1 seropositivity was associated with increased risk of oral cavity and oropharyngeal cancer (OR 1.94, 95% confidence interval [CI] 1.03 to 3.65; OR 8.60, 95% CI 5.21 to 14.20, respectively). HPV16 E6 antibodies were present in 30.2% of oropharyngeal case subjects and only 0.8% of control subjects (OR 132.0, 95% CI 65.29 to 266.86). Combined seropositivity to HPV16 E6 and E7 was rare (n 1 of 1425 control subjects). An agreement of 67% was observed between HPV16 E6 serology and the correspondin
Název v anglickém jazyce
Human Papillomavirus Infections and Upper Aero-Digestive Tract Cancers: The ARCAGE Study
Popis výsledku anglicky
Human papillomavirus (HPV) is causally implicated in a subset of cancers of the upper aero-digestive tract (UADT). Associations between type-specific HPV antibodies were examined among 1496 UADT cancer case subjects and 1425 control subjects by estimating odds ratios (ORs) in logistic regression analyses adjusted for potential confounders. The agreement between serology and tumor markers of HPV infection, including presence of HPV DNA and p16 expression, were examined in a subset of tumors. HPV16 L1 seropositivity was associated with increased risk of oral cavity and oropharyngeal cancer (OR 1.94, 95% confidence interval [CI] 1.03 to 3.65; OR 8.60, 95% CI 5.21 to 14.20, respectively). HPV16 E6 antibodies were present in 30.2% of oropharyngeal case subjects and only 0.8% of control subjects (OR 132.0, 95% CI 65.29 to 266.86). Combined seropositivity to HPV16 E6 and E7 was rare (n 1 of 1425 control subjects). An agreement of 67% was observed between HPV16 E6 serology and the correspondin
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FD - Onkologie a hematologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
R - Projekt Ramcoveho programu EK
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of the National Cancer Institute
ISSN
0027-8874
e-ISSN
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Svazek periodika
105
Číslo periodika v rámci svazku
8
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
10
Strana od-do
536-545
Kód UT WoS článku
000318089100006
EID výsledku v databázi Scopus
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