Prolonged overdose of all-trans retinoic acid enhances bone sensitivity in castrated mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10189375" target="_blank" >RIV/00216208:11110/13:10189375 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61383082:_____/13:0022 RIV/00064165:_____/13:10189375

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.nut.2013.03.011" target="_blank" >http://dx.doi.org/10.1016/j.nut.2013.03.011</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.nut.2013.03.011" target="_blank" >10.1016/j.nut.2013.03.011</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Prolonged overdose of all-trans retinoic acid enhances bone sensitivity in castrated mice

Popis výsledku v původním jazyce

Objectives: Intake of multivitamin preparations is very common in developed countries. However, excessive intake of vitamin A was associated with increased bone fragility. The aim of this study was to determine if chronic administration of the active metabolite of vitamin A all-trans-retinoic acid (ATRA) in slight excess is associated with changes of bone turnover and density in intact and castrated mice. Method: Three mo old male mice (C57B1/6) intact and castrated were injected intraperitonealy with 10 mg/kg/d of the ATRA or vehicle (control) once daily for 3 wk. The bone density, ash weights, calcium, and phosphorus content of the femur were measured. Plasma tartrate-resistant acid phosphatase (Tr-ACP) and serum bone alkaline phosphatase (B-ALP) were determined. Results: ATRA decreased bone density in both groups; however, this effect was more pronounced in castrated animals (1.487 +/- 0.04 to 1,360 +/- 0.05 g/cm(3)) than in intact mice (1.570 +/- 0.03 to 1.510 +/- 0.03 g/cm(3)). Bo

Název v anglickém jazyce

Prolonged overdose of all-trans retinoic acid enhances bone sensitivity in castrated mice

Popis výsledku anglicky

Objectives: Intake of multivitamin preparations is very common in developed countries. However, excessive intake of vitamin A was associated with increased bone fragility. The aim of this study was to determine if chronic administration of the active metabolite of vitamin A all-trans-retinoic acid (ATRA) in slight excess is associated with changes of bone turnover and density in intact and castrated mice. Method: Three mo old male mice (C57B1/6) intact and castrated were injected intraperitonealy with 10 mg/kg/d of the ATRA or vehicle (control) once daily for 3 wk. The bone density, ash weights, calcium, and phosphorus content of the femur were measured. Plasma tartrate-resistant acid phosphatase (Tr-ACP) and serum bone alkaline phosphatase (B-ALP) were determined. Results: ATRA decreased bone density in both groups; however, this effect was more pronounced in castrated animals (1.487 +/- 0.04 to 1,360 +/- 0.05 g/cm(3)) than in intact mice (1.570 +/- 0.03 to 1.510 +/- 0.03 g/cm(3)). Bo

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/NT11335" target="_blank" >NT11335: Kostní metabolismus u pacientů s diabetes mellitus 2. typu: úloha receptoru pro pokročilé produkty glykace (RAGE) a polymorfismů jeho genu</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nutrition

ISSN

0899-9007

e-ISSN

—

Svazek periodika

29

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

4

Strana od-do

1166-1169

Kód UT WoS článku

000323235500016

EID výsledku v databázi Scopus

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