Availability of Haematopoietic Niches for Transplanted Stem Cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10189439" target="_blank" >RIV/00216208:11110/13:10189439 - isvavai.cz</a>

Výsledek na webu

<a href="http://fb.cuni.cz/file/5666/FB2013A0001.pdf" target="_blank" >http://fb.cuni.cz/file/5666/FB2013A0001.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Availability of Haematopoietic Niches for Transplanted Stem Cells

Popis výsledku v původním jazyce

Following transplantation, donor haematopoietic stem cells (HSCs) must reach specific parts of haematopoietic stroma tissue known as stem cell niches to become engrafted and to start blood cell production. Regularly, they have to compete with the host'sHSCs for a limited number of niches. The exact mechanisms of HSC engraftment as well as of niche "opening" to incoming HSCs by conditioning treatments are not well-known yet. Significant and stable engraftment of syngeneic donor HSCs can be achieved in untreated mice only after transplantation of very large numbers of marrow cells. Engraftment can be largely facilitated by the stem cell mutations reducing numbers of the host HSCs. Pre-transplantation manipulations of the host haematopoietic tissue enhance engraftment depending on how much they damage HSCs. Ionizing radiation appears to be the most effective in this respect despite proliferative quiescence of a majority of HSCs. The review summarizes major achievements in deciphering bio

Název v anglickém jazyce

Availability of Haematopoietic Niches for Transplanted Stem Cells

Popis výsledku anglicky

Following transplantation, donor haematopoietic stem cells (HSCs) must reach specific parts of haematopoietic stroma tissue known as stem cell niches to become engrafted and to start blood cell production. Regularly, they have to compete with the host'sHSCs for a limited number of niches. The exact mechanisms of HSC engraftment as well as of niche "opening" to incoming HSCs by conditioning treatments are not well-known yet. Significant and stable engraftment of syngeneic donor HSCs can be achieved in untreated mice only after transplantation of very large numbers of marrow cells. Engraftment can be largely facilitated by the stem cell mutations reducing numbers of the host HSCs. Pre-transplantation manipulations of the host haematopoietic tissue enhance engraftment depending on how much they damage HSCs. Ionizing radiation appears to be the most effective in this respect despite proliferative quiescence of a majority of HSCs. The review summarizes major achievements in deciphering bio

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Folia Biologica

ISSN

0015-5500

e-ISSN

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Svazek periodika

59

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

14

Strana od-do

1-14

Kód UT WoS článku

000326215200001

EID výsledku v databázi Scopus

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