Sex, Food and Threat: Startling Changes after Subthalamic Stimulation in Parkinson's Disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10189558" target="_blank" >RIV/00216208:11110/13:10189558 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21230/13:00208419 RIV/00064165:_____/13:10189558 RIV/00023884:_____/12:00007608

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.brs.2013.03.009" target="_blank" >http://dx.doi.org/10.1016/j.brs.2013.03.009</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.brs.2013.03.009" target="_blank" >10.1016/j.brs.2013.03.009</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Sex, Food and Threat: Startling Changes after Subthalamic Stimulation in Parkinson's Disease

Popis výsledku v původním jazyce

Background: Changes in motivational processing may play a role in weight gain and other non-motor side effects in Parkinson's disease (PD) patients treated with deep brain stimulation of the subthalamic nucleus. Objective/hypothesis: We aimed to assess changes in aversive and appetitive motivational activation using modulation of the acoustic blink reflex (ABR) by rewarding and aversive stimuli. Methods: ABR elicited during the viewing of erotic, food, aversive and neutral pictures was recorded in 11 off-medicated patients with the subthalamic stimulation switched ON and OFF, and in 11 control subjects. Results: ABR to erotic stimuli was larger in patients in the ON compared to the OFF condition and controls (P < 0.01). Aversive stimuli caused a largerincrease in the ABR in patients with the ON condition than in controls (P < 0.05). Additionally, we found a negative correlation of the ABR magnitude to food pictures in the ON condition with weight gain following subthalamic stimulation

Název v anglickém jazyce

Sex, Food and Threat: Startling Changes after Subthalamic Stimulation in Parkinson's Disease

Popis výsledku anglicky

Background: Changes in motivational processing may play a role in weight gain and other non-motor side effects in Parkinson's disease (PD) patients treated with deep brain stimulation of the subthalamic nucleus. Objective/hypothesis: We aimed to assess changes in aversive and appetitive motivational activation using modulation of the acoustic blink reflex (ABR) by rewarding and aversive stimuli. Methods: ABR elicited during the viewing of erotic, food, aversive and neutral pictures was recorded in 11 off-medicated patients with the subthalamic stimulation switched ON and OFF, and in 11 control subjects. Results: ABR to erotic stimuli was larger in patients in the ON compared to the OFF condition and controls (P < 0.01). Aversive stimuli caused a largerincrease in the ABR in patients with the ON condition than in controls (P < 0.05). Additionally, we found a negative correlation of the ABR magnitude to food pictures in the ON condition with weight gain following subthalamic stimulation

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Brain Stimulation

ISSN

1935-861X

e-ISSN

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Svazek periodika

6

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

740-745

Kód UT WoS článku

000325046600006

EID výsledku v databázi Scopus

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