Serum and cerebrospinal fluid heavy neurofilaments and antibodies against them in early multiple sclerosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10190240" target="_blank" >RIV/00216208:11110/13:10190240 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/13:43907457 RIV/00064173:_____/13:#0000338 RIV/00023752:_____/13:43914444 RIV/00064165:_____/13:10190240

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jneuroim.2013.03.009" target="_blank" >http://dx.doi.org/10.1016/j.jneuroim.2013.03.009</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jneuroim.2013.03.009" target="_blank" >10.1016/j.jneuroim.2013.03.009</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Serum and cerebrospinal fluid heavy neurofilaments and antibodies against them in early multiple sclerosis

Popis výsledku v původním jazyce

Heavy neurofilaments (NFH) released from neurons during axonal injury induce a humoral immune response. We measured CSF and serum levels of NFH proteins and anti-NFH IgG antibodies in 19 patients with clinically isolated syndrome (CIS) converting to multiple sclerosis, in 20 stable CIS patients, 23 patients with multiple sclerosis (MS) and 32 control subjects using ELISA. CSF and intrathecal levels and CSF/serum ratios of anti-NFH antibodies were increased in the CIS patients early developing MS while NFH protein concentrations were similar among the groups. Changes associated with NFH are more pronounced for antibodies than for protein itself and may aid in prediction of CIS patients.

Název v anglickém jazyce

Serum and cerebrospinal fluid heavy neurofilaments and antibodies against them in early multiple sclerosis

Popis výsledku anglicky

Heavy neurofilaments (NFH) released from neurons during axonal injury induce a humoral immune response. We measured CSF and serum levels of NFH proteins and anti-NFH IgG antibodies in 19 patients with clinically isolated syndrome (CIS) converting to multiple sclerosis, in 20 stable CIS patients, 23 patients with multiple sclerosis (MS) and 32 control subjects using ELISA. CSF and intrathecal levels and CSF/serum ratios of anti-NFH antibodies were increased in the CIS patients early developing MS while NFH protein concentrations were similar among the groups. Changes associated with NFH are more pronounced for antibodies than for protein itself and may aid in prediction of CIS patients.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/NT13183" target="_blank" >NT13183: Krátké psychometrické metody ke včasné diagnostice Alzheimerovy nemoci u seniorské populace</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Neuroimmunology

ISSN

0165-5728

e-ISSN

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Svazek periodika

259

Číslo periodika v rámci svazku

1-2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

81-87

Kód UT WoS článku

000319848100010

EID výsledku v databázi Scopus

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