Mitochondrial respiration in blood platelets of depressive patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10190649" target="_blank" >RIV/00216208:11110/13:10190649 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/13:10190649

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.mito.2013.05.005" target="_blank" >http://dx.doi.org/10.1016/j.mito.2013.05.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.mito.2013.05.005" target="_blank" >10.1016/j.mito.2013.05.005</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mitochondrial respiration in blood platelets of depressive patients

Popis výsledku v původním jazyce

Recent evidences include mitochondrial dysfunctions in pathophysiology of mood disorders. We examined association between depressive disorders and mitochondrial respiration using both intact and permeabilized blood platelets. In intact platelets, physiological respiration, maximal capacity of electron transport system and respiratory rate after complex I inhibition were decreased in depressive patients, who reached partial remission, compared to healthy controls. Respiratory rates were unchanged in several respiratory states in permeabilized platelets. Results indicate that changes in respiratory rate in intact platelets can be used as biological marker of depressive disorder. The hypothesis that decreased mitochondrial respiratory rate participate inpathophysiology of depression was supported.

Název v anglickém jazyce

Mitochondrial respiration in blood platelets of depressive patients

Popis výsledku anglicky

Recent evidences include mitochondrial dysfunctions in pathophysiology of mood disorders. We examined association between depressive disorders and mitochondrial respiration using both intact and permeabilized blood platelets. In intact platelets, physiological respiration, maximal capacity of electron transport system and respiratory rate after complex I inhibition were decreased in depressive patients, who reached partial remission, compared to healthy controls. Respiratory rates were unchanged in several respiratory states in permeabilized platelets. Results indicate that changes in respiratory rate in intact platelets can be used as biological marker of depressive disorder. The hypothesis that decreased mitochondrial respiratory rate participate inpathophysiology of depression was supported.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FL - Psychiatrie, sexuologie

OECD FORD obor

—

Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mitochondrion

ISSN

1567-7249

e-ISSN

—

Svazek periodika

13

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

795-800

Kód UT WoS článku

000327280500029

EID výsledku v databázi Scopus

—