Plasma cortisol in Alzheimer's disease with or without depressive symptoms

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10190651" target="_blank" >RIV/00216208:11110/13:10190651 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/13:10190651

Výsledek na webu

<a href="http://dx.doi.org/10.12659/MSM.889110" target="_blank" >http://dx.doi.org/10.12659/MSM.889110</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.12659/MSM.889110" target="_blank" >10.12659/MSM.889110</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Plasma cortisol in Alzheimer's disease with or without depressive symptoms

Popis výsledku v původním jazyce

Background: Cortisol is presumed to be a risk factor for stress-and age-related disorders, such as depressive disorder and Alzheimer's disease (AD). The aim of this study was to investigate the association of plasma cortisol concentration with AD in presence or absence of comorbid depressive symptoms. Material/Methods: Plasma cortisol concentration was measured in 80 AD patients (35 of them with depressive symptoms), 27 elderly depressive patients without AD, and 37 elderly controls. Results: Compared to controls, a significant increase of mean plasma cortisol was found in AD patients but not in depressive patients. Plasma cortisol was positively correlated with cognitive impairment in AD patients. We confirmed a U-shaped association between plasma cortisol and major depression and a linear association between plasma cortisol and AD without depressive symptoms. Significantly increased relative risk of disease in people with high plasma cortisol was found for AD with depressive symptoms

Název v anglickém jazyce

Plasma cortisol in Alzheimer's disease with or without depressive symptoms

Popis výsledku anglicky

Background: Cortisol is presumed to be a risk factor for stress-and age-related disorders, such as depressive disorder and Alzheimer's disease (AD). The aim of this study was to investigate the association of plasma cortisol concentration with AD in presence or absence of comorbid depressive symptoms. Material/Methods: Plasma cortisol concentration was measured in 80 AD patients (35 of them with depressive symptoms), 27 elderly depressive patients without AD, and 37 elderly controls. Results: Compared to controls, a significant increase of mean plasma cortisol was found in AD patients but not in depressive patients. Plasma cortisol was positively correlated with cognitive impairment in AD patients. We confirmed a U-shaped association between plasma cortisol and major depression and a linear association between plasma cortisol and AD without depressive symptoms. Significantly increased relative risk of disease in people with high plasma cortisol was found for AD with depressive symptoms

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FL - Psychiatrie, sexuologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Medical Science Monitor [online]

ISSN

1643-3750

e-ISSN

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Svazek periodika

Neuveden

Číslo periodika v rámci svazku

19

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

9

Strana od-do

681-689

Kód UT WoS článku

000323181300001

EID výsledku v databázi Scopus

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