Cytokines and Chemokines as Biomarkers of Community-Acquired Bacterial Infection

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10191060" target="_blank" >RIV/00216208:11110/13:10191060 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064211:_____/13:#0000223

Výsledek na webu

<a href="http://dx.doi.org/10.1155/2013/190145" target="_blank" >http://dx.doi.org/10.1155/2013/190145</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2013/190145" target="_blank" >10.1155/2013/190145</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cytokines and Chemokines as Biomarkers of Community-Acquired Bacterial Infection

Popis výsledku v původním jazyce

Routinely used biomarkers of bacterial etiology of infection, such as C-reactive protein and procalcitonin, have limited usefulness for evaluation of infections since their expression is enhanced by a number of different conditions. Therefore, several inflammatory cytokines and chemokines were analyzed with sera from patients hospitalized for moderate bacterial and viral infectious diseases. In total, 57 subjects were enrolled: 21 patients with community-acquired bacterial infections, 26 patients with viral infections, and 10 healthy subjects (control cohorts). The laboratory analyses were performed using Luminex technology, and the following molecules were examined: IL-1Ra, IL-2, IL-4, IL-6, IL-8, TNF-alpha, INF-gamma, MIP-1 beta, and MCP-1. Bacterialetiology of infection was associated with significantly (P < 0.001) elevated serum concentrations of IL-1Ra, IL-2, IL-6, and TNF-alpha in comparison to levels observed in the sera of patients with viral infections. In the patients with b

Název v anglickém jazyce

Cytokines and Chemokines as Biomarkers of Community-Acquired Bacterial Infection

Popis výsledku anglicky

Routinely used biomarkers of bacterial etiology of infection, such as C-reactive protein and procalcitonin, have limited usefulness for evaluation of infections since their expression is enhanced by a number of different conditions. Therefore, several inflammatory cytokines and chemokines were analyzed with sera from patients hospitalized for moderate bacterial and viral infectious diseases. In total, 57 subjects were enrolled: 21 patients with community-acquired bacterial infections, 26 patients with viral infections, and 10 healthy subjects (control cohorts). The laboratory analyses were performed using Luminex technology, and the following molecules were examined: IL-1Ra, IL-2, IL-4, IL-6, IL-8, TNF-alpha, INF-gamma, MIP-1 beta, and MCP-1. Bacterialetiology of infection was associated with significantly (P < 0.001) elevated serum concentrations of IL-1Ra, IL-2, IL-6, and TNF-alpha in comparison to levels observed in the sera of patients with viral infections. In the patients with b

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FN - Epidemiologie, infekční nemoci a klinická imunologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mediators of Inflammation

ISSN

0962-9351

e-ISSN

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Svazek periodika

Neuveden.

Číslo periodika v rámci svazku

Aut

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

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Kód UT WoS článku

000318080600001

EID výsledku v databázi Scopus

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