MITF: a Critical Transcription Factor in Melanoma Transcriptional Regulatory Network

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10191824" target="_blank" >RIV/00216208:11110/13:10191824 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.5772/55191" target="_blank" >http://dx.doi.org/10.5772/55191</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5772/55191" target="_blank" >10.5772/55191</a>

Jazyk výsledku

angličtina

Název v původním jazyce

MITF: a Critical Transcription Factor in Melanoma Transcriptional Regulatory Network

Popis výsledku v původním jazyce

Melanocytes are specialized cells found predominantly in the skin and eyes that form the pigment melanin. Melanocytes are found also in a benign nevus, a common lesion observed in the skin which is a precursor of malignant melanoma. Sporadic cases of melanoma predominate and can be grouped into four clinical subtypes: acral lentiginous melanoma, nodular melanoma, lentigo maligna and superficial spreading melanoma. About 60-70% of melanomas harbour mutations of the B-RAF gene, while mutations of the N-RAS are present in about 10-25% of all tumors. Many other genes are deregulated during melanoma progression, mainly antiapoptotic genes and gene which are involved in the invasiveness, migration, and metastasis of melanoma, many of which are regulated by MITF-M (microphthalmia-associated transcription factor), a pivotal transcription factor of the melanocyte lineage.

Název v anglickém jazyce

MITF: a Critical Transcription Factor in Melanoma Transcriptional Regulatory Network

Popis výsledku anglicky

Melanocytes are specialized cells found predominantly in the skin and eyes that form the pigment melanin. Melanocytes are found also in a benign nevus, a common lesion observed in the skin which is a precursor of malignant melanoma. Sporadic cases of melanoma predominate and can be grouped into four clinical subtypes: acral lentiginous melanoma, nodular melanoma, lentigo maligna and superficial spreading melanoma. About 60-70% of melanomas harbour mutations of the B-RAF gene, while mutations of the N-RAS are present in about 10-25% of all tumors. Many other genes are deregulated during melanoma progression, mainly antiapoptotic genes and gene which are involved in the invasiveness, migration, and metastasis of melanoma, many of which are regulated by MITF-M (microphthalmia-associated transcription factor), a pivotal transcription factor of the melanocyte lineage.

Druh

C - Kapitola v odborné knize

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

—

Projekt

<a href="/cs/project/NT11229" target="_blank" >NT11229: Transkripční faktor MITF ? klíčový regulátor proliferace a přežívání melanomových buněk a molekulární cíl protinádorové terapie</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Recent Advances in the Biology, Therapy and Management of Melanoma

ISBN

978-953-51-0976-1

Počet stran výsledku

11

Strana od-do

71-81

Počet stran knihy

375

Název nakladatele

InTech

Místo vydání

Rijeka, Croatia

Kód UT WoS kapitoly

—