Development of gray matter atrophy in relapsing-remitting multiple sclerosis is not gender dependent: Results of a 5-year follow-up study
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10192196" target="_blank" >RIV/00216208:11110/13:10192196 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00064165:_____/13:10192196
Výsledek na webu
<a href="http://dx.doi.org/10.1016/j.clineuro.2013.09.020" target="_blank" >http://dx.doi.org/10.1016/j.clineuro.2013.09.020</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.clineuro.2013.09.020" target="_blank" >10.1016/j.clineuro.2013.09.020</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Development of gray matter atrophy in relapsing-remitting multiple sclerosis is not gender dependent: Results of a 5-year follow-up study
Popis výsledku v původním jazyce
Objectives The aim of this study was to explore the evolution of MRI related gender differences in patients with relapsing-remitting (RR) multiple sclerosis (MS) who participated in a clinical trial over the 5 years. Methods 181 patients (39 males and 142 females) were assessed for clinical and neuroradiological disease activity over a period of 5 years. Clinical and MRI examination were performed at the baseline, 6, 12, 24, 36, 48 and 60 months. Longitudinal percentage volume changes in whole brain (PBVC), gray matter (PGMVC) white matter (PWMVC) cortex (PCVC), and lateral ventricles (PLVVC) were calculated by using direct methods (SIENA and SIENAX-multitimepoint). Absolute tissue volume changes of subcortical deep GM structures including caudate, putamen, globus pallidus, thalamus, hippocampus, amygdala and nucleus accumbens were estimated using FIRST, a model based segmentation/registration tool. T2 lesion volume (T2-LV) and lesion activity analyses were performed, using a contourin
Název v anglickém jazyce
Development of gray matter atrophy in relapsing-remitting multiple sclerosis is not gender dependent: Results of a 5-year follow-up study
Popis výsledku anglicky
Objectives The aim of this study was to explore the evolution of MRI related gender differences in patients with relapsing-remitting (RR) multiple sclerosis (MS) who participated in a clinical trial over the 5 years. Methods 181 patients (39 males and 142 females) were assessed for clinical and neuroradiological disease activity over a period of 5 years. Clinical and MRI examination were performed at the baseline, 6, 12, 24, 36, 48 and 60 months. Longitudinal percentage volume changes in whole brain (PBVC), gray matter (PGMVC) white matter (PWMVC) cortex (PCVC), and lateral ventricles (PLVVC) were calculated by using direct methods (SIENA and SIENAX-multitimepoint). Absolute tissue volume changes of subcortical deep GM structures including caudate, putamen, globus pallidus, thalamus, hippocampus, amygdala and nucleus accumbens were estimated using FIRST, a model based segmentation/registration tool. T2 lesion volume (T2-LV) and lesion activity analyses were performed, using a contourin
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FH - Neurologie, neurochirurgie, neurovědy
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/NT13237" target="_blank" >NT13237: Klinické a paraklinické markery roztroušené sklerózy – korelace se současným stavem pacienta a predikce průběhu nemoci.</a><br>
Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Clinical Neurology and Neurosurgery
ISSN
0303-8467
e-ISSN
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Svazek periodika
115
Číslo periodika v rámci svazku
S1
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
7
Strana od-do
"S42"-"S48"
Kód UT WoS článku
000330417700009
EID výsledku v databázi Scopus
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