Pathophysiology of Mood Disorders and Mechanisms of Action of Antidepressants and Mood Stabilizers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10193047" target="_blank" >RIV/00216208:11110/13:10193047 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/978-1-4614-7940-6_6" target="_blank" >http://dx.doi.org/10.1007/978-1-4614-7940-6_6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-1-4614-7940-6_6" target="_blank" >10.1007/978-1-4614-7940-6_6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Pathophysiology of Mood Disorders and Mechanisms of Action of Antidepressants and Mood Stabilizers

Popis výsledku v původním jazyce

The chapter summarizes information on the pathophysiology of mood disorders and biochemical mechanisms of action of antidepressants and mood stabilizers with focus on an endocannabinoid regulation of monoamines in depression and bipolar disorder. Leadingrole in neurochemistry and pathophysiology of mood disorders could be awarded to disturbed monoamine neurotransmission, dysfunction in energy metabolism of neurons, modulation of inflammatory and neuroendocrine pathways, and changes in activities of transcription factors, neurotrophic factors and other components involved in neuroplasticity. A role of endocannabinoid system in pathophysiology of mood disorders is supposed, but little known. In the light of new findings, there is potential for pharmacological regulation of endocannabinoid system in treatment of depressive and bipolar disorder.

Název v anglickém jazyce

Pathophysiology of Mood Disorders and Mechanisms of Action of Antidepressants and Mood Stabilizers

Popis výsledku anglicky

The chapter summarizes information on the pathophysiology of mood disorders and biochemical mechanisms of action of antidepressants and mood stabilizers with focus on an endocannabinoid regulation of monoamines in depression and bipolar disorder. Leadingrole in neurochemistry and pathophysiology of mood disorders could be awarded to disturbed monoamine neurotransmission, dysfunction in energy metabolism of neurons, modulation of inflammatory and neuroendocrine pathways, and changes in activities of transcription factors, neurotrophic factors and other components involved in neuroplasticity. A role of endocannabinoid system in pathophysiology of mood disorders is supposed, but little known. In the light of new findings, there is potential for pharmacological regulation of endocannabinoid system in treatment of depressive and bipolar disorder.

Druh

C - Kapitola v odborné knize

CEP obor

FL - Psychiatrie, sexuologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders

ISBN

978-1-4614-7939-0

Počet stran výsledku

32

Strana od-do

103-134

Počet stran knihy

337

Název nakladatele

Springer

Místo vydání

New York

Kód UT WoS kapitoly

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