Folate Deficiency Is Associated With Oxidative Stress, Increased Blood Pressure, and Insulin Resistance in Spontaneously Hypertensive Rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10193131" target="_blank" >RIV/00216208:11110/13:10193131 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/13:00392092 RIV/00023001:_____/13:00058533 RIV/00064165:_____/13:10193131

Výsledek na webu

<a href="http://dx.doi.org/10.1093/ajh/hps015" target="_blank" >http://dx.doi.org/10.1093/ajh/hps015</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/ajh/hps015" target="_blank" >10.1093/ajh/hps015</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Folate Deficiency Is Associated With Oxidative Stress, Increased Blood Pressure, and Insulin Resistance in Spontaneously Hypertensive Rats

Popis výsledku v původním jazyce

BACKGROUND The role of folate deficiency and associated hyperhomocysteinemia in the pathogenesis of metabolic syndrome is not fully established. In the current study, we analyzed the role of folate deficiency in pathogenesis of the metabolic syndrome inthe spontaneously hypertensive rat (SHR). METHODS Metabolic and hemodynamic traits were assessed in SHR/Ola rats fed either folate-deficient or control diet for 4 weeks starting at the age of 3 months. RESULTS Compared to SHRs fed a folate-replete diet,SHRs fed a folate-deficient diet showed significantly reduced serum folate (104 +/- 5 vs. 11 +/- 1 nmol/L, P < 0.0005) and urinary folate excretion (4.3 +/- 0.6 vs. 1.2 +/- 0.1 nmol/16 h, P < 0.0005) together with a near 3-fold increase in plasma total homocysteine concentration (4.5 +/- 0.1 vs 13.1 +/- 0.7 mu mol/L, P < 0.0005), ectopic fat accumulation in liver, and impaired glucose tolerance. Folate deficiency also increased systolic blood pressure by approximately 15 mm Hg (P < 0.01)

Název v anglickém jazyce

Folate Deficiency Is Associated With Oxidative Stress, Increased Blood Pressure, and Insulin Resistance in Spontaneously Hypertensive Rats

Popis výsledku anglicky

BACKGROUND The role of folate deficiency and associated hyperhomocysteinemia in the pathogenesis of metabolic syndrome is not fully established. In the current study, we analyzed the role of folate deficiency in pathogenesis of the metabolic syndrome inthe spontaneously hypertensive rat (SHR). METHODS Metabolic and hemodynamic traits were assessed in SHR/Ola rats fed either folate-deficient or control diet for 4 weeks starting at the age of 3 months. RESULTS Compared to SHRs fed a folate-replete diet,SHRs fed a folate-deficient diet showed significantly reduced serum folate (104 +/- 5 vs. 11 +/- 1 nmol/L, P < 0.0005) and urinary folate excretion (4.3 +/- 0.6 vs. 1.2 +/- 0.1 nmol/16 h, P < 0.0005) together with a near 3-fold increase in plasma total homocysteine concentration (4.5 +/- 0.1 vs 13.1 +/- 0.7 mu mol/L, P < 0.0005), ectopic fat accumulation in liver, and impaired glucose tolerance. Folate deficiency also increased systolic blood pressure by approximately 15 mm Hg (P < 0.01)

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American Journal of Hypertension

ISSN

0895-7061

e-ISSN

—

Svazek periodika

26

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

135-140

Kód UT WoS článku

000313972600019

EID výsledku v databázi Scopus

—