Stress Perception and (GT)n Repeat Polymorphism in Haem Oxygenase 1 Promoter Are Both Risk Factors in Development of Eating Disorders

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10193340" target="_blank" >RIV/00216208:11110/13:10193340 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11410/13:10193340 RIV/00064165:_____/13:10193340

Výsledek na webu

<a href="http://fb.cuni.cz/file/5706/FB2013A0033.pdf" target="_blank" >http://fb.cuni.cz/file/5706/FB2013A0033.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Stress Perception and (GT)n Repeat Polymorphism in Haem Oxygenase 1 Promoter Are Both Risk Factors in Development of Eating Disorders

Popis výsledku v původním jazyce

Haem oxygenase 1 (HO-1) plays a pivotal role in metabolic stress protecting cells in dependence on reactive oxygen species. This study investigated a potential gene environment interaction between the (GT)n repeat HO1 polymorphism and the stress perception in patients with eating disorder and in controls. Stress perception and (GT)n polymorphism were measured in 127 patients with eating disorders and in 78 healthy controls using Stress and Coping Inventory and genotyping. Based on the inventory, overall, specific and weighted stress scores were defined. Clinical stress score was generated according to the patient's history and interviews. According to our hypothesis, 1) all stress scores describing subjective stress perception were significantly higherin patients compared to controls (P LESS-THAN OR EQUAL TO 0.001; P LESS-THAN OR EQUAL TO 0.002; P LESS-THAN OR EQUAL TO 0.001), 2) the L/L genotype of GT promoter repeats (L < 25 GT repeats, S < 25 GT repeats) in the patients was associa

Název v anglickém jazyce

Stress Perception and (GT)n Repeat Polymorphism in Haem Oxygenase 1 Promoter Are Both Risk Factors in Development of Eating Disorders

Popis výsledku anglicky

Haem oxygenase 1 (HO-1) plays a pivotal role in metabolic stress protecting cells in dependence on reactive oxygen species. This study investigated a potential gene environment interaction between the (GT)n repeat HO1 polymorphism and the stress perception in patients with eating disorder and in controls. Stress perception and (GT)n polymorphism were measured in 127 patients with eating disorders and in 78 healthy controls using Stress and Coping Inventory and genotyping. Based on the inventory, overall, specific and weighted stress scores were defined. Clinical stress score was generated according to the patient's history and interviews. According to our hypothesis, 1) all stress scores describing subjective stress perception were significantly higherin patients compared to controls (P LESS-THAN OR EQUAL TO 0.001; P LESS-THAN OR EQUAL TO 0.002; P LESS-THAN OR EQUAL TO 0.001), 2) the L/L genotype of GT promoter repeats (L < 25 GT repeats, S < 25 GT repeats) in the patients was associa

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FL - Psychiatrie, sexuologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT14094" target="_blank" >NT14094: Genetické a environmentální faktory u poruch příjmu potravy. Nové endofenotypy a genetické přístupy.</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Folia Biologica

ISSN

0015-5500

e-ISSN

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Svazek periodika

59

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

233-239

Kód UT WoS článku

000330161600004

EID výsledku v databázi Scopus

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