Myeloid related protein induces muscle derived inflammatory mediators in juvenile dermatomyositis
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10193357" target="_blank" >RIV/00216208:11110/13:10193357 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00064165:_____/13:10193357
Výsledek na webu
<a href="http://dx.doi.org/10.1186/ar4311" target="_blank" >http://dx.doi.org/10.1186/ar4311</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/ar4311" target="_blank" >10.1186/ar4311</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Myeloid related protein induces muscle derived inflammatory mediators in juvenile dermatomyositis
Popis výsledku v původním jazyce
Introduction: The aetiopathogenesis of juvenile dermatomyositis (JDM) remains poorly understood. In particular the contribution of monocytes or macrophages, which are frequently observed to be an infiltrate within muscle tissue very early in the diseaseprocess, is unknown. We hypothesised that these cells secrete the pro-inflammatory myeloid related protein (MRP) 8/14 which may then contribute to muscle pathology in JDM. Methods: In this study of 56 JDM patients, serum MRP8/14 levels were compared withclinical measures of disease activity. Muscle biopsies taken early in disease were assessed by immunohistochemistry to determine the frequency and identity of MRP-expressing cells. The effects of MRP stimulation and endoplasmic reticulum (ER) stress onmuscle were tested in vitro. Serum or supernatant levels of cytokines were analyzed by multiplex immunoassay. Results: Serum MRP8/14 correlated with physician's global assessment of disease activity in JDM (R = 0.65, p = 0.0003) and muscl
Název v anglickém jazyce
Myeloid related protein induces muscle derived inflammatory mediators in juvenile dermatomyositis
Popis výsledku anglicky
Introduction: The aetiopathogenesis of juvenile dermatomyositis (JDM) remains poorly understood. In particular the contribution of monocytes or macrophages, which are frequently observed to be an infiltrate within muscle tissue very early in the diseaseprocess, is unknown. We hypothesised that these cells secrete the pro-inflammatory myeloid related protein (MRP) 8/14 which may then contribute to muscle pathology in JDM. Methods: In this study of 56 JDM patients, serum MRP8/14 levels were compared withclinical measures of disease activity. Muscle biopsies taken early in disease were assessed by immunohistochemistry to determine the frequency and identity of MRP-expressing cells. The effects of MRP stimulation and endoplasmic reticulum (ER) stress onmuscle were tested in vitro. Serum or supernatant levels of cytokines were analyzed by multiplex immunoassay. Results: Serum MRP8/14 correlated with physician's global assessment of disease activity in JDM (R = 0.65, p = 0.0003) and muscl
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FG - Pediatrie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
R - Projekt Ramcoveho programu EK
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Arthritis Research & Therapy
ISSN
1478-6362
e-ISSN
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Svazek periodika
15
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
11
Strana od-do
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Kód UT WoS článku
000329737400031
EID výsledku v databázi Scopus
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