A common biological basis of obesity and nicotine addiction

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10193436" target="_blank" >RIV/00216208:11110/13:10193436 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/13:33144515 RIV/61988987:17110/13:A1601AW7

Výsledek na webu

<a href="http://dx.doi.org/10.1038/tp.2013.81" target="_blank" >http://dx.doi.org/10.1038/tp.2013.81</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/tp.2013.81" target="_blank" >10.1038/tp.2013.81</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A common biological basis of obesity and nicotine addiction

Popis výsledku v původním jazyce

Smoking influences body weight such that smokers weigh less than non-smokers and smoking cessation often leads to weight increase. The relationship between body weight and smoking is partly explained by the effect of nicotine on appetite and metabolism.However, the brain reward system is involved in the control of the intake of both food and tobacco. We evaluated the effect of single-nucleotide polymorphisms (SNPs) affecting body mass index (BMI) on smoking behavior, and tested the 32 SNPs identified in a meta-analysis for association with two smoking phenotypes, smoking initiation (SI) and the number of cigarettes smoked per day (CPD) in an Icelandic sample (N=34 216 smokers). Combined according to their effect on BMI, the SNPs correlate with both SI(r=0.019, P=0.00054) and CPD (r=0.032, P=8.0 x 10-7). These findings replicate in a second large data set (N=127 274, thereof 76 242 smokers) for both SI (P=1.2 x 10-5) and CPD (P=9.3 x 10-5). Notably, the variant most strongly associate

Název v anglickém jazyce

A common biological basis of obesity and nicotine addiction

Popis výsledku anglicky

Smoking influences body weight such that smokers weigh less than non-smokers and smoking cessation often leads to weight increase. The relationship between body weight and smoking is partly explained by the effect of nicotine on appetite and metabolism.However, the brain reward system is involved in the control of the intake of both food and tobacco. We evaluated the effect of single-nucleotide polymorphisms (SNPs) affecting body mass index (BMI) on smoking behavior, and tested the 32 SNPs identified in a meta-analysis for association with two smoking phenotypes, smoking initiation (SI) and the number of cigarettes smoked per day (CPD) in an Icelandic sample (N=34 216 smokers). Combined according to their effect on BMI, the SNPs correlate with both SI(r=0.019, P=0.00054) and CPD (r=0.032, P=8.0 x 10-7). These findings replicate in a second large data set (N=127 274, thereof 76 242 smokers) for both SI (P=1.2 x 10-5) and CPD (P=9.3 x 10-5). Notably, the variant most strongly associate

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FM - Hygiena

OECD FORD obor

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Projekt

—

Návaznosti

R - Projekt Ramcoveho programu EK

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Translational Psychiatry

ISSN

2158-3188

e-ISSN

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Svazek periodika

3

Číslo periodika v rámci svazku

Oct 1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

1-7

Kód UT WoS článku

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EID výsledku v databázi Scopus

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