Markers of HPV infection and survival in patients with head and neck tumors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10194021" target="_blank" >RIV/00216208:11110/13:10194021 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023736:_____/13:00010734 RIV/00216208:11130/13:10194021 RIV/00064203:_____/13:10194021

Výsledek na webu

<a href="http://dx.doi.org/10.1002/ijc.28194" target="_blank" >http://dx.doi.org/10.1002/ijc.28194</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ijc.28194" target="_blank" >10.1002/ijc.28194</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Markers of HPV infection and survival in patients with head and neck tumors

Popis výsledku v původním jazyce

The purpose of this study was to determine whether changes in human papillomavirus (HPV) DNA prevalence in oral rinses and/or HPV-specific antibody levels in the sera of patients with oral/oropharyngeal cancer have prognostic significance. We enrolled 142 patients with oral/oropharyngeal tumors. The presence of HPV DNA was assayed in tumor tissue and oral rinses and HPV-specific antibodies were assessed in the sera. Oral rinses and sera were collected before and after the treatment. Altogether, 59.2% oftumors were HPV positive. The presence of HPV DNA in the tumors correlated with HPV DNA positivity in oral rinses and with HPV-specific antibodies in the sera. Out of 66 patients with HPV-positive oral rinses at enrolment, 84.8% became negative after the therapy, while most patients remained seropositive for HPV-specific antigens. However, the mean titers of HPV16 E6 and/or E7 antibodies at follow-up were significantly lower. Of 16 patients with recurrences at follow-up, six were positi

Název v anglickém jazyce

Markers of HPV infection and survival in patients with head and neck tumors

Popis výsledku anglicky

The purpose of this study was to determine whether changes in human papillomavirus (HPV) DNA prevalence in oral rinses and/or HPV-specific antibody levels in the sera of patients with oral/oropharyngeal cancer have prognostic significance. We enrolled 142 patients with oral/oropharyngeal tumors. The presence of HPV DNA was assayed in tumor tissue and oral rinses and HPV-specific antibodies were assessed in the sera. Oral rinses and sera were collected before and after the treatment. Altogether, 59.2% oftumors were HPV positive. The presence of HPV DNA in the tumors correlated with HPV DNA positivity in oral rinses and with HPV-specific antibodies in the sera. Out of 66 patients with HPV-positive oral rinses at enrolment, 84.8% became negative after the therapy, while most patients remained seropositive for HPV-specific antigens. However, the mean titers of HPV16 E6 and/or E7 antibodies at follow-up were significantly lower. Of 16 patients with recurrences at follow-up, six were positi

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FF - ORL, oftalmologie, stomatologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Cancer

ISSN

0020-7136

e-ISSN

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Svazek periodika

133

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

1832-1839

Kód UT WoS článku

000322908600008

EID výsledku v databázi Scopus

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