Metabolic changes in the auditory cortex in presbycusis demonstrated by MR spectroscopy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10195073" target="_blank" >RIV/00216208:11110/13:10195073 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/13:00395434 RIV/00023001:_____/13:00058654 RIV/00064203:_____/13:10195073

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.exger.2013.04.012" target="_blank" >http://dx.doi.org/10.1016/j.exger.2013.04.012</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.exger.2013.04.012" target="_blank" >10.1016/j.exger.2013.04.012</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Metabolic changes in the auditory cortex in presbycusis demonstrated by MR spectroscopy

Popis výsledku v původním jazyce

In humans, aging is accompanied by the deterioration of the hearing function - presbycusis. The major etiology for presbycusis is the loss of hair cells in the inner ear; less well known are changes in the central auditory system. Therefore, we used 1 Hmagnetic resonance spectroscopy at 3 T tomograph to examine metabolite levels in the auditory cortex of three groups of subjects: young healthy subjects less than 30 years old and subjects older than 65 years either with mild presbycusis corresponding totheir age or with expressed presbycusis. Hearing function in all subjects was examined by pure tone audiometry (125-16000 Hz). Significant differences were found in the concentrations of glutamate and N-acetylaspartate, with lower levels in aged subjects. Lactate was particularly increased in subjects with expressed presbycusis. Significant differences were not found in other metabolites, including GABA, between young and elderly subjects. The results demonstrate that the age-related ch

Název v anglickém jazyce

Metabolic changes in the auditory cortex in presbycusis demonstrated by MR spectroscopy

Popis výsledku anglicky

In humans, aging is accompanied by the deterioration of the hearing function - presbycusis. The major etiology for presbycusis is the loss of hair cells in the inner ear; less well known are changes in the central auditory system. Therefore, we used 1 Hmagnetic resonance spectroscopy at 3 T tomograph to examine metabolite levels in the auditory cortex of three groups of subjects: young healthy subjects less than 30 years old and subjects older than 65 years either with mild presbycusis corresponding totheir age or with expressed presbycusis. Hearing function in all subjects was examined by pure tone audiometry (125-16000 Hz). Significant differences were found in the concentrations of glutamate and N-acetylaspartate, with lower levels in aged subjects. Lactate was particularly increased in subjects with expressed presbycusis. Significant differences were not found in other metabolites, including GABA, between young and elderly subjects. The results demonstrate that the age-related ch

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

—

Projekt

<a href="/cs/project/GAP304%2F10%2F1872" target="_blank" >GAP304/10/1872: Vliv stárnutí na sluchovou kůru člověka - MR studie</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Experimental Gerontology

ISSN

0531-5565

e-ISSN

—

Svazek periodika

48

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

16

Strana od-do

795-800

Kód UT WoS článku

000321700300014

EID výsledku v databázi Scopus

—