Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development

Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10195292" target="_blank" >RIV/00216208:11110/13:10195292 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00064165:_____/13:10195292
Výsledek na webu
<a href="http://dx.doi.org/10.1371/journal.pmed.1001551" target="_blank" >http://dx.doi.org/10.1371/journal.pmed.1001551</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pmed.1001551" target="_blank" >10.1371/journal.pmed.1001551</a>

Jazyk výsledku
angličtina
Název v původním jazyce
Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development
Popis výsledku v původním jazyce
Background: Endometrial cancer incidence is continuing to rise in the wake of the current ageing and obesity epidemics. Much of the risk for endometrial cancer development is influenced by the environment and lifestyle. Accumulating evidence suggests that the epigenome serves as the interface between the genome and the environment and that hypermethylation of stem cell polycomb group target genes is an epigenetic hallmark of cancer. The objective of this study was to determine the functional role of epigenetic factors in endometrial cancer development.
Název v anglickém jazyce
Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development
Popis výsledku anglicky
Background: Endometrial cancer incidence is continuing to rise in the wake of the current ageing and obesity epidemics. Much of the risk for endometrial cancer development is influenced by the environment and lifestyle. Accumulating evidence suggests that the epigenome serves as the interface between the genome and the environment and that hypermethylation of stem cell polycomb group target genes is an epigenetic hallmark of cancer. The objective of this study was to determine the functional role of epigenetic factors in endometrial cancer development.

Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FK - Gynekologie a porodnictví
OECD FORD obor
—

Projekt
<a href="/cs/project/7E13033" target="_blank" >7E13033: Epigenetics for female personalized cancer care</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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