Synthetic Polyamine BPA-C8 Inhibits TGF-beta 1-Mediated Conversion of Human Dermal Fibroblast to Myofibroblasts and Establishment of Galectin-1-Rich Extracellular Matrix in Vitro

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10272179" target="_blank" >RIV/00216208:11110/14:10272179 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/14:10272179

Výsledek na webu

<a href="http://dx.doi.org/10.1002/cbic.201402087" target="_blank" >http://dx.doi.org/10.1002/cbic.201402087</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/cbic.201402087" target="_blank" >10.1002/cbic.201402087</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthetic Polyamine BPA-C8 Inhibits TGF-beta 1-Mediated Conversion of Human Dermal Fibroblast to Myofibroblasts and Establishment of Galectin-1-Rich Extracellular Matrix in Vitro

Popis výsledku v původním jazyce

Cancer-associated fibroblasts (CAFs) play a role in the progression of malignant tumors. They are formed by conversion of fibroblasts to smooth muscle alpha-actin-positive (SMA-positive) myofibroblasts. Polyamines are known to change the arrangement of the actin cytoskeleton by binding to the anionic actin. We tested the effect of the synthetic polyamine BPA-C8 on the transition of human dermal fibroblasts to myofibroblasts induced either by TGF-beta 1 alone or by TGF-beta 1 together with adhesion/growth-regulatory galectin-1. Pre-existing CAFs, myofi-broblasts from pancreatitis, and rat smooth muscle cells were also exposed to BPA-C8. BPA-C8 impaired myofibroblast formation from activated fibroblasts, but it had no effect on cells already expressing SMA. BPA-C8 also reduced the occurrence of an extracellular matrix around the activated fibroblasts. The reported data thus extend current insights into polyamine activity, adding interference with tumor progression to the tumor-promoting

Název v anglickém jazyce

Synthetic Polyamine BPA-C8 Inhibits TGF-beta 1-Mediated Conversion of Human Dermal Fibroblast to Myofibroblasts and Establishment of Galectin-1-Rich Extracellular Matrix in Vitro

Popis výsledku anglicky

Cancer-associated fibroblasts (CAFs) play a role in the progression of malignant tumors. They are formed by conversion of fibroblasts to smooth muscle alpha-actin-positive (SMA-positive) myofibroblasts. Polyamines are known to change the arrangement of the actin cytoskeleton by binding to the anionic actin. We tested the effect of the synthetic polyamine BPA-C8 on the transition of human dermal fibroblasts to myofibroblasts induced either by TGF-beta 1 alone or by TGF-beta 1 together with adhesion/growth-regulatory galectin-1. Pre-existing CAFs, myofi-broblasts from pancreatitis, and rat smooth muscle cells were also exposed to BPA-C8. BPA-C8 impaired myofibroblast formation from activated fibroblasts, but it had no effect on cells already expressing SMA. BPA-C8 also reduced the occurrence of an extracellular matrix around the activated fibroblasts. The reported data thus extend current insights into polyamine activity, adding interference with tumor progression to the tumor-promoting

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EA - Morfologické obory a cytologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chembiochem : a European journal of chemical biology

ISSN

1439-4227

e-ISSN

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Svazek periodika

15

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

6

Strana od-do

1465-1470

Kód UT WoS článku

000338769300014

EID výsledku v databázi Scopus

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