The leiomyomatous stroma in renal cell carcinomas is polyclonal and not part of the neoplastic process

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10282579" target="_blank" >RIV/00216208:11110/14:10282579 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11140/14:10282579 RIV/00216208:11150/14:10282579 RIV/00179906:_____/14:10282579

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00428-014-1591-9" target="_blank" >http://dx.doi.org/10.1007/s00428-014-1591-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00428-014-1591-9" target="_blank" >10.1007/s00428-014-1591-9</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The leiomyomatous stroma in renal cell carcinomas is polyclonal and not part of the neoplastic process

Popis výsledku v původním jazyce

Some renal epithelial neoplasms, such as renal angiomyoadenomatous tumor, clear cell papillary renal cell carcinoma and renal cell carcinoma with smooth muscle stroma, contain a variably prominent smooth muscle stromal component. Whether or not this leiomyomatous stroma is part of the neoplastic proliferation has not been firmly established. We studied the clonality status of 14 renal cell carcinomas with a prominent smooth muscle stromal component (four renal angiomyoadenomatous tumors/clear cell papillary carcinomas, five clear cell carcinomas, two papillary carcinomas, and three renal cell carcinomas with smooth muscle rich stroma) using the human androgen receptor assay (HUMARA). We found the leiomyomatous stromal component in all analyzable (8/14)cases to be polyclonal and therefore reactive rather than neoplastic. Based on morphological observations, we propose that the non-neoplastic leiomyomatous stromal component is likely derived from smooth muscle cells of large caliber vei

Název v anglickém jazyce

The leiomyomatous stroma in renal cell carcinomas is polyclonal and not part of the neoplastic process

Popis výsledku anglicky

Some renal epithelial neoplasms, such as renal angiomyoadenomatous tumor, clear cell papillary renal cell carcinoma and renal cell carcinoma with smooth muscle stroma, contain a variably prominent smooth muscle stromal component. Whether or not this leiomyomatous stroma is part of the neoplastic proliferation has not been firmly established. We studied the clonality status of 14 renal cell carcinomas with a prominent smooth muscle stromal component (four renal angiomyoadenomatous tumors/clear cell papillary carcinomas, five clear cell carcinomas, two papillary carcinomas, and three renal cell carcinomas with smooth muscle rich stroma) using the human androgen receptor assay (HUMARA). We found the leiomyomatous stromal component in all analyzable (8/14)cases to be polyclonal and therefore reactive rather than neoplastic. Based on morphological observations, we propose that the non-neoplastic leiomyomatous stromal component is likely derived from smooth muscle cells of large caliber vei

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Virchows Archiv : an international journal of pathology

ISSN

0945-6317

e-ISSN

—

Svazek periodika

465

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

89-96

Kód UT WoS článku

000338728000010

EID výsledku v databázi Scopus

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