Dual Role of Host Par2 in a Murine Model of Spontaneous Metastatic B16 Melanoma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10282788" target="_blank" >RIV/00216208:11110/14:10282788 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/14:00432084 RIV/00064190:_____/14:#0000802 RIV/68407700:21340/14:00223755 RIV/00216208:11120/14:43908600

Výsledek na webu

<a href="http://ar.iiarjournals.org/content/34/7/3511" target="_blank" >http://ar.iiarjournals.org/content/34/7/3511</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Dual Role of Host Par2 in a Murine Model of Spontaneous Metastatic B16 Melanoma

Popis výsledku v původním jazyce

Aim: We investigated differences of metastatic spread of normal proteinase-activated receptor-2 (Par2(+/+)) melanoma B16 in Par2(-/-) (knock-out) animals compared to C57Bl6 mice. Materials and Methods: Nine knock-out mice B6.Cg-F2rl1tm1Mslb/J (Par2(-/-))and nine C57Bl6/J controls were subcutaneously inoculated with B16 melanoma tissue cells. Twelve days after inoculation, all primary tumors were removed. Survival and metastatic spread was followed for up to 100 days after primary tumor extirpation. Results: Excised primary tumors were on average larger in Par2(-/-) mice (360 mm(3) vs. 221 mm(3) in C57Bl6/J). Distant spontaneous metastases developed in only 3 of 9 of Par2(-/-) mice in comparison to 6 of 9 controls. The average survival time was 84 daysin Par2(-/-) animals compared to 63 days in C57Bl6/J mice. Conclusion: Host Par2 melanoma model contributes to the limitation of local cancer progression in one area, while on the other hand is important for enhancing distant metastatic

Název v anglickém jazyce

Dual Role of Host Par2 in a Murine Model of Spontaneous Metastatic B16 Melanoma

Popis výsledku anglicky

Aim: We investigated differences of metastatic spread of normal proteinase-activated receptor-2 (Par2(+/+)) melanoma B16 in Par2(-/-) (knock-out) animals compared to C57Bl6 mice. Materials and Methods: Nine knock-out mice B6.Cg-F2rl1tm1Mslb/J (Par2(-/-))and nine C57Bl6/J controls were subcutaneously inoculated with B16 melanoma tissue cells. Twelve days after inoculation, all primary tumors were removed. Survival and metastatic spread was followed for up to 100 days after primary tumor extirpation. Results: Excised primary tumors were on average larger in Par2(-/-) mice (360 mm(3) vs. 221 mm(3) in C57Bl6/J). Distant spontaneous metastases developed in only 3 of 9 of Par2(-/-) mice in comparison to 6 of 9 controls. The average survival time was 84 daysin Par2(-/-) animals compared to 63 days in C57Bl6/J mice. Conclusion: Host Par2 melanoma model contributes to the limitation of local cancer progression in one area, while on the other hand is important for enhancing distant metastatic

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Anticancer Research

ISSN

0250-7005

e-ISSN

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Svazek periodika

34

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

GR - Řecká republika

Počet stran výsledku

5

Strana od-do

3511-3515

Kód UT WoS článku

000338780300036

EID výsledku v databázi Scopus

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