Avidity of antiphospholipid antibodies - our current knowledge

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10282818" target="_blank" >RIV/00216208:11110/14:10282818 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.prolekare.cz/linkout/50383" target="_blank" >http://www.prolekare.cz/linkout/50383</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Avidity of antiphospholipid antibodies - our current knowledge

Popis výsledku v původním jazyce

Antiphospholipid antibodies (APL), which represent serum markers of the antiphospholipid syndrome, comprise an extremely heterogeneous group of autoantibodies directed against various phospholipids and protein cofactors. The heterogeneity of APL includesnot only their antigen-binding site specificity but also their avidity. The aim of this study was to summarize the current knowledge about commonly-used procedures for the avidity determination with a special interest in the antiphospholipid antibodiesand to evaluate the clinical significance of APL avidity determination. The common techniques in clinical laboratories for avidity determination utilize the ELISAs in the presence of various chaotropic agents. The findings of clinical studies suggest that the high avidity APL are associated with thrombosis and antiphospholipid syndrom (APS). The determination of APL avidity might be a complementary laboratory marker applicable in the classification of APS.

Název v anglickém jazyce

Avidity of antiphospholipid antibodies - our current knowledge

Popis výsledku anglicky

Antiphospholipid antibodies (APL), which represent serum markers of the antiphospholipid syndrome, comprise an extremely heterogeneous group of autoantibodies directed against various phospholipids and protein cofactors. The heterogeneity of APL includesnot only their antigen-binding site specificity but also their avidity. The aim of this study was to summarize the current knowledge about commonly-used procedures for the avidity determination with a special interest in the antiphospholipid antibodiesand to evaluate the clinical significance of APL avidity determination. The common techniques in clinical laboratories for avidity determination utilize the ELISAs in the presence of various chaotropic agents. The findings of clinical studies suggest that the high avidity APL are associated with thrombosis and antiphospholipid syndrom (APS). The determination of APL avidity might be a complementary laboratory marker applicable in the classification of APS.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Epidemiologie, Mikrobiologie, Imunologie

ISSN

1210-7913

e-ISSN

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Svazek periodika

63

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

220-224

Kód UT WoS článku

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EID výsledku v databázi Scopus

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