Fermitin-3 fragmentation observed in the platelets of patients with cardiovascular diseases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10283500" target="_blank" >RIV/00216208:11110/14:10283500 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023736:_____/14:00011075 RIV/61383082:_____/14:#0000273 RIV/00216208:11130/14:10283500 RIV/00064203:_____/14:10283500

Výsledek na webu

<a href="http://cardiologyacademicpress.com/soap/pdf/delme_2112_53e55098040d23.99688914.pdf" target="_blank" >http://cardiologyacademicpress.com/soap/pdf/delme_2112_53e55098040d23.99688914.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Fermitin-3 fragmentation observed in the platelets of patients with cardiovascular diseases

Popis výsledku v původním jazyce

Platelets are essential for primary hemostasis, but they also play a key role in the development of acute coronary syndrome. Moreover, platelets also promote an inflammatory reaction connected with atherosclerosis. The aim of this pilot study was to search for platelet proteome changes in a patient cohort with cardiovascular diseases, in comparison with a group of young healthy donors. 23 platelet samples (patients with acute coronary syndrome n=8, patients with stable angina pectoris n=7, and control group n=8) were used in this work. Platelets were isolated by centrifugation, and platelet proteins were separated using 2D SDS-PAGE. Proteins were identified and further analyzed using nanoLC-MS/MS. In total, 33 spots were observed to differ significantly between the studied groups; they corresponded to 53 different proteins. The proteome changes were found to be identical or closely related to the platelet proteome changes induced by platelet activation. Fragmentation of fermitin family

Název v anglickém jazyce

Fermitin-3 fragmentation observed in the platelets of patients with cardiovascular diseases

Popis výsledku anglicky

Platelets are essential for primary hemostasis, but they also play a key role in the development of acute coronary syndrome. Moreover, platelets also promote an inflammatory reaction connected with atherosclerosis. The aim of this pilot study was to search for platelet proteome changes in a patient cohort with cardiovascular diseases, in comparison with a group of young healthy donors. 23 platelet samples (patients with acute coronary syndrome n=8, patients with stable angina pectoris n=7, and control group n=8) were used in this work. Platelets were isolated by centrifugation, and platelet proteins were separated using 2D SDS-PAGE. Proteins were identified and further analyzed using nanoLC-MS/MS. In total, 33 spots were observed to differ significantly between the studied groups; they corresponded to 53 different proteins. The proteome changes were found to be identical or closely related to the platelet proteome changes induced by platelet activation. Fragmentation of fermitin family

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

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Projekt

<a href="/cs/project/GBP205%2F12%2FG118" target="_blank" >GBP205/12/G118: Nanobiofotonika pro medicínu budoucnosti</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Experimental and Clinical Cardiology

ISSN

1205-6626

e-ISSN

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Svazek periodika

20

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

CA - Kanada

Počet stran výsledku

5

Strana od-do

2881-2885

Kód UT WoS článku

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EID výsledku v databázi Scopus

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