Bad and Bid - potential background players in preneoplastic to neoplastic shift in human endometrium

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10284445" target="_blank" >RIV/00216208:11110/14:10284445 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/14:00439233 RIV/00216208:11310/14:10284445 RIV/00064211:_____/14:#0000321

Výsledek na webu

<a href="http://dx.doi.org/10.4149/neo_2014_050" target="_blank" >http://dx.doi.org/10.4149/neo_2014_050</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/neo_2014_050" target="_blank" >10.4149/neo_2014_050</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Bad and Bid - potential background players in preneoplastic to neoplastic shift in human endometrium

Popis výsledku v původním jazyce

The most common malignancies of the female genital tract are endometrial carcinomas, whose are generally proceeded by hyperplasia. The maintenance of tissue homeostasis is to great extent governed by apoptosis, whose defects can lead to the preneoplasticand/or cancerous changes. Endometrial apoptosis involves among others three groups of proteins of the Bcl-2 family. First group contains anti-apoptotic proteins (e. g. Bcl-2, Bcl-xL). The other two groups belong to the pro-apoptotic proteins with three(e. g. Bax, Bak) or one (e. g. Bad, Bid) so-called BH domains. Bad and Bid trigger the oligomerization of Bak and Ban protein, which permeabilize the outer mitochondrial wall. Unlike Bid, Bad cannot directly trigger apoptosis. Instead, Bad lowers the threshold at which apoptosis is induced, by binding anti-apoptotic Bcl-2 proteins. However, their mutual counterbalance or synergism in the human endometrium has not been reported yet. In this study, the levels of Bid and Bad were measured u

Název v anglickém jazyce

Bad and Bid - potential background players in preneoplastic to neoplastic shift in human endometrium

Popis výsledku anglicky

The most common malignancies of the female genital tract are endometrial carcinomas, whose are generally proceeded by hyperplasia. The maintenance of tissue homeostasis is to great extent governed by apoptosis, whose defects can lead to the preneoplasticand/or cancerous changes. Endometrial apoptosis involves among others three groups of proteins of the Bcl-2 family. First group contains anti-apoptotic proteins (e. g. Bcl-2, Bcl-xL). The other two groups belong to the pro-apoptotic proteins with three(e. g. Bax, Bak) or one (e. g. Bad, Bid) so-called BH domains. Bad and Bid trigger the oligomerization of Bak and Ban protein, which permeabilize the outer mitochondrial wall. Unlike Bid, Bad cannot directly trigger apoptosis. Instead, Bad lowers the threshold at which apoptosis is induced, by binding anti-apoptotic Bcl-2 proteins. However, their mutual counterbalance or synergism in the human endometrium has not been reported yet. In this study, the levels of Bid and Bad were measured u

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FK - Gynekologie a porodnictví

OECD FORD obor

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Projekt

<a href="/cs/project/GAP207%2F12%2F0919" target="_blank" >GAP207/12/0919: Úloha hydrofobní zóny plasmatické membrány v regulaci funkční aktivity trimerních G proteinů receptorem pro opioidy typu delta</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neoplasma

ISSN

0028-2685

e-ISSN

—

Svazek periodika

61

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

5

Strana od-do

411-415

Kód UT WoS článku

000342881700005

EID výsledku v databázi Scopus

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