Selective In Vitro Anticancer Effect of Superparamagnetic Iron Oxide Nanoparticles Loaded in Hyaluronan Polymeric Micelles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10284489" target="_blank" >RIV/00216208:11110/14:10284489 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/14:00059076

Výsledek na webu

<a href="http://dx.doi.org/10.1021/bm501065q" target="_blank" >http://dx.doi.org/10.1021/bm501065q</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/bm501065q" target="_blank" >10.1021/bm501065q</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Selective In Vitro Anticancer Effect of Superparamagnetic Iron Oxide Nanoparticles Loaded in Hyaluronan Polymeric Micelles

Popis výsledku v původním jazyce

Due to its native origin, excellent biocompatibility and biodegradability, hyaluronan (HA) represents an attractive polymer for superparamagnetic iron oxide nanoparticles (SPION) coating. Herein, we report HA polymeric micelles encapsulating oleic acid coated SPIONs, having a hydrodynamic size of about 100 nm and SPION loading capacity of 12 wt %. The HA-SPION polymeric micelles were found to be selectively cytotoxic toward a number of human cancer cell lines, mainly those of colon adenocarcinoma (HT-29). The selective inhibition of cell growth was even observed when the SPION loaded HA polymeric micelles were incubated with a mixture of control and cancer cells. The selective in vitro inhibition could not be connected with an enhanced CD44 uptake or radical oxygen species formation and was rather connected with a different way of SPION intracellular release. While aggregated iron particles were visualized in control cells, nonaggregated solubilized iron oxide particles were detected i

Název v anglickém jazyce

Selective In Vitro Anticancer Effect of Superparamagnetic Iron Oxide Nanoparticles Loaded in Hyaluronan Polymeric Micelles

Popis výsledku anglicky

Due to its native origin, excellent biocompatibility and biodegradability, hyaluronan (HA) represents an attractive polymer for superparamagnetic iron oxide nanoparticles (SPION) coating. Herein, we report HA polymeric micelles encapsulating oleic acid coated SPIONs, having a hydrodynamic size of about 100 nm and SPION loading capacity of 12 wt %. The HA-SPION polymeric micelles were found to be selectively cytotoxic toward a number of human cancer cell lines, mainly those of colon adenocarcinoma (HT-29). The selective inhibition of cell growth was even observed when the SPION loaded HA polymeric micelles were incubated with a mixture of control and cancer cells. The selective in vitro inhibition could not be connected with an enhanced CD44 uptake or radical oxygen species formation and was rather connected with a different way of SPION intracellular release. While aggregated iron particles were visualized in control cells, nonaggregated solubilized iron oxide particles were detected i

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomacromolecules

ISSN

1525-7797

e-ISSN

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Svazek periodika

15

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

4012-4020

Kód UT WoS článku

000344721400015

EID výsledku v databázi Scopus

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