Expression of BAFF receptors in muscle tissue of myositis patients with anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10284516" target="_blank" >RIV/00216208:11110/14:10284516 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.biomedcentral.com/content/pdf/s13075-014-0454-8.pdf" target="_blank" >http://www.biomedcentral.com/content/pdf/s13075-014-0454-8.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s13075-014-0454-8" target="_blank" >10.1186/s13075-014-0454-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Expression of BAFF receptors in muscle tissue of myositis patients with anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies

Popis výsledku v původním jazyce

Anti-Jo-1 and anti-Ro52 autoantibodies are common in patients with myositis. Survival of autoantibody-producing cells is dependent on B-cell-activating factor of the tumour necrosis factor family (BAFF). BAFF levels are elevated in serum of anti-Jo-1-positive myositis patients and are influenced by type-I interferon (IFN). IFN-producing cells and BAFF mRNA expression are present in myositis muscle. We have investigated expression of the receptors for BAFF in muscle tissue and found their association toserum autoantibodies and muscle expression of type-I IFN markers. The expression pattern of receptors for BAFF on B and plasma cells in muscle suggests a possible local role for BAFF in autoantibody production in muscle tissues of patients with myositiswho have anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies.

Název v anglickém jazyce

Expression of BAFF receptors in muscle tissue of myositis patients with anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies

Popis výsledku anglicky

Anti-Jo-1 and anti-Ro52 autoantibodies are common in patients with myositis. Survival of autoantibody-producing cells is dependent on B-cell-activating factor of the tumour necrosis factor family (BAFF). BAFF levels are elevated in serum of anti-Jo-1-positive myositis patients and are influenced by type-I interferon (IFN). IFN-producing cells and BAFF mRNA expression are present in myositis muscle. We have investigated expression of the receptors for BAFF in muscle tissue and found their association toserum autoantibodies and muscle expression of type-I IFN markers. The expression pattern of receptors for BAFF on B and plasma cells in muscle suggests a possible local role for BAFF in autoantibody production in muscle tissues of patients with myositiswho have anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

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Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Arthritis Research and Therapy

ISSN

1478-6354

e-ISSN

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Svazek periodika

16

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

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Kód UT WoS článku

000349885900033

EID výsledku v databázi Scopus

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