Effects of teriparatide on cortical histomorphometric variables in postmenopausal women with or without prior alendronate treatment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10285482" target="_blank" >RIV/00216208:11110/14:10285482 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/14:10285482

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.bone.2013.11.011" target="_blank" >http://dx.doi.org/10.1016/j.bone.2013.11.011</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bone.2013.11.011" target="_blank" >10.1016/j.bone.2013.11.011</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effects of teriparatide on cortical histomorphometric variables in postmenopausal women with or without prior alendronate treatment

Popis výsledku v původním jazyce

Cortical bone, the dominant component of the human skeleton by volume, plays a key role in protecting bones from fracture. We analyzed the cortical bone effects of teriparatide treatment in postmenopausal women with osteoporosis who had previously received long-term alendronate (ALN) therapy or were treatment naive (TN). Tetracycline-labeled paired iliac crest biopsies obtained from 29 ALN-pretreated and 16 TN women were evaluated for dynamic histomorphometric parameters of bone formation at the periosteal, endocortical and intracortical bone compartments, before and after 24 months of teriparatide treatment. At baseline, the frequency of specimens without any endocortical and periosteal tetracycline labeling, and the percentage of quiescent osteons, was higher in the ALN than the TN group. Endocortical and periosteal mineralizing surface (MS/BS%), periosteal bone formation rate (BFR/BS), mineral apposition rate (MAR) and the number of intracortical forming osteons were significantly l

Název v anglickém jazyce

Effects of teriparatide on cortical histomorphometric variables in postmenopausal women with or without prior alendronate treatment

Popis výsledku anglicky

Cortical bone, the dominant component of the human skeleton by volume, plays a key role in protecting bones from fracture. We analyzed the cortical bone effects of teriparatide treatment in postmenopausal women with osteoporosis who had previously received long-term alendronate (ALN) therapy or were treatment naive (TN). Tetracycline-labeled paired iliac crest biopsies obtained from 29 ALN-pretreated and 16 TN women were evaluated for dynamic histomorphometric parameters of bone formation at the periosteal, endocortical and intracortical bone compartments, before and after 24 months of teriparatide treatment. At baseline, the frequency of specimens without any endocortical and periosteal tetracycline labeling, and the percentage of quiescent osteons, was higher in the ALN than the TN group. Endocortical and periosteal mineralizing surface (MS/BS%), periosteal bone formation rate (BFR/BS), mineral apposition rate (MAR) and the number of intracortical forming osteons were significantly l

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

—

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bone

ISSN

8756-3282

e-ISSN

—

Svazek periodika

59

Číslo periodika v rámci svazku

February

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

139-147

Kód UT WoS článku

000329558600018

EID výsledku v databázi Scopus

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