Distinct chromatin organization in the germ line founder cell of the Caenorhabditis elegans embryo

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10285509" target="_blank" >RIV/00216208:11110/14:10285509 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1111/dgd.12160" target="_blank" >http://dx.doi.org/10.1111/dgd.12160</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/dgd.12160" target="_blank" >10.1111/dgd.12160</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Distinct chromatin organization in the germ line founder cell of the Caenorhabditis elegans embryo

Popis výsledku v původním jazyce

Cells belonging to the germ lineage segregate physically and molecularly from their somatic neighbors during embryogenesis. While germ line-specific chromatin modifications have been identified at later stages in the Caenorhabditis elegans nematode, nonehave been found in the single P-4 germ line founder cell that arises at the beginning of gastrulation. Using light and electron microscopy, we now report that the chromatin organization in the germ line founder cell of the early C.elegans embryo is distinct from that in the neighboring somatic cells. This unique organization is characterized by a greater chromatin compaction and an expansion of the interchromatin compartment. The ultrastructure of individual chromatin domains does not differ between germ line and somatic cells, pointing to a specific organization mainly at the level of the whole nucleus. We show that this higher order reorganization of chromatin is not a consequence of the P-4 nucleus being smaller than somatic nuclei

Název v anglickém jazyce

Distinct chromatin organization in the germ line founder cell of the Caenorhabditis elegans embryo

Popis výsledku anglicky

Cells belonging to the germ lineage segregate physically and molecularly from their somatic neighbors during embryogenesis. While germ line-specific chromatin modifications have been identified at later stages in the Caenorhabditis elegans nematode, nonehave been found in the single P-4 germ line founder cell that arises at the beginning of gastrulation. Using light and electron microscopy, we now report that the chromatin organization in the germ line founder cell of the early C.elegans embryo is distinct from that in the neighboring somatic cells. This unique organization is characterized by a greater chromatin compaction and an expansion of the interchromatin compartment. The ultrastructure of individual chromatin domains does not differ between germ line and somatic cells, pointing to a specific organization mainly at the level of the whole nucleus. We show that this higher order reorganization of chromatin is not a consequence of the P-4 nucleus being smaller than somatic nuclei

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Development Growth and Differentiation

ISSN

0012-1592

e-ISSN

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Svazek periodika

56

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

JP - Japonsko

Počet stran výsledku

10

Strana od-do

605-614

Kód UT WoS článku

000346479200002

EID výsledku v databázi Scopus

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