MRI correlates of disability progression in patients with CIS over 48 months

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10285638" target="_blank" >RIV/00216208:11110/14:10285638 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/14:10285638

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.nicl.2014.09.015" target="_blank" >http://dx.doi.org/10.1016/j.nicl.2014.09.015</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.nicl.2014.09.015" target="_blank" >10.1016/j.nicl.2014.09.015</a>

Jazyk výsledku

angličtina

Název v původním jazyce

MRI correlates of disability progression in patients with CIS over 48 months

Popis výsledku v původním jazyce

Background Gray matter (GM) and white matter (WM) pathology has an important role in disease progression of multiple sclerosis (MS). Objectives To investigate the association between the development of GM and WM pathology and clinical disease progressionin patients with clinically isolated syndrome (CIS). Methods This prospective, observational, 48-month follow-up study examined 210 CIS patients treated with 30 ?g of intramuscular interferon beta-1a once a week. MRI and clinical assessments were performed at baseline, 6, 12, 24, 36 and 48 months. Associations between clinical worsening [24-weeks sustained disability progression (SDP) and occurrence of a second clinical attack] and longitudinal changes in lesion accumulation and brain atrophy progression were investigated by a mixed-effect model analysis after correction for multiple comparisons. Results SDP was observed in 32 (15.2%) CIS patients, while 146 (69.5%) were stable and 32 (15.2%) showed sustained disability improvement. 11

Název v anglickém jazyce

MRI correlates of disability progression in patients with CIS over 48 months

Popis výsledku anglicky

Background Gray matter (GM) and white matter (WM) pathology has an important role in disease progression of multiple sclerosis (MS). Objectives To investigate the association between the development of GM and WM pathology and clinical disease progressionin patients with clinically isolated syndrome (CIS). Methods This prospective, observational, 48-month follow-up study examined 210 CIS patients treated with 30 ?g of intramuscular interferon beta-1a once a week. MRI and clinical assessments were performed at baseline, 6, 12, 24, 36 and 48 months. Associations between clinical worsening [24-weeks sustained disability progression (SDP) and occurrence of a second clinical attack] and longitudinal changes in lesion accumulation and brain atrophy progression were investigated by a mixed-effect model analysis after correction for multiple comparisons. Results SDP was observed in 32 (15.2%) CIS patients, while 146 (69.5%) were stable and 32 (15.2%) showed sustained disability improvement. 11

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/NT13237" target="_blank" >NT13237: Klinické a paraklinické markery roztroušené sklerózy – korelace se současným stavem pacienta a predikce průběhu nemoci.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

NeuroImage: Clinical

ISSN

2213-1582

e-ISSN

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Svazek periodika

6

Číslo periodika v rámci svazku

september

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

312-319

Kód UT WoS článku

000349668500035

EID výsledku v databázi Scopus

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