Humoral Immune Responses to HIV in the Mucosal Secretions and Sera of HIV- Infected

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10285775" target="_blank" >RIV/00216208:11110/14:10285775 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1111/aji.12203" target="_blank" >http://dx.doi.org/10.1111/aji.12203</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/aji.12203" target="_blank" >10.1111/aji.12203</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Humoral Immune Responses to HIV in the Mucosal Secretions and Sera of HIV- Infected

Popis výsledku v původním jazyce

Although sera and all external secretions contain antibodies to human immunodeficiency virus (HIV), their levels, specificity, isotypes, and relevant effector functions display a great degree of variability. Antibodies that bind HIV antigens and neutralize the virus are predominantly associated with the IgG isotype in sera and in all external secretions, even where total levels of IgG are much lower than those of IgA. Rectal fluid that contains high IgA, but low IgG levels, displayed low neutralizing activity independent of antibodies. Therefore, external secretions should be evaluated before and after selective depletion of Ig. At the systemic level, HIV-specific IgA may interfere with the effector functions of IgG, as suggested by recent studies of individuals systemically immunized with an experimental HIV vaccine. Although HIV-specific IgG and IgA antibodies may exhibit their protective activities at mucosal surfaces through interference with viral entry and local neutralization at

Název v anglickém jazyce

Humoral Immune Responses to HIV in the Mucosal Secretions and Sera of HIV- Infected

Popis výsledku anglicky

Although sera and all external secretions contain antibodies to human immunodeficiency virus (HIV), their levels, specificity, isotypes, and relevant effector functions display a great degree of variability. Antibodies that bind HIV antigens and neutralize the virus are predominantly associated with the IgG isotype in sera and in all external secretions, even where total levels of IgG are much lower than those of IgA. Rectal fluid that contains high IgA, but low IgG levels, displayed low neutralizing activity independent of antibodies. Therefore, external secretions should be evaluated before and after selective depletion of Ig. At the systemic level, HIV-specific IgA may interfere with the effector functions of IgG, as suggested by recent studies of individuals systemically immunized with an experimental HIV vaccine. Although HIV-specific IgG and IgA antibodies may exhibit their protective activities at mucosal surfaces through interference with viral entry and local neutralization at

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American Journal of Reproductive Immunology

ISSN

1046-7408

e-ISSN

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Svazek periodika

71

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

DK - Dánské království

Počet stran výsledku

8

Strana od-do

600-607

Kód UT WoS článku

000335917600014

EID výsledku v databázi Scopus

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