Clinical features of childhood granulomatosis with polyangiitis (wegener's granulomatosis)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10286343" target="_blank" >RIV/00216208:11110/14:10286343 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/14:10286343

Výsledek na webu

<a href="http://dx.doi.org/10.1186/1546-0096-12-18" target="_blank" >http://dx.doi.org/10.1186/1546-0096-12-18</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1546-0096-12-18" target="_blank" >10.1186/1546-0096-12-18</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Clinical features of childhood granulomatosis with polyangiitis (wegener's granulomatosis)

Popis výsledku v původním jazyce

Background: Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis (WG), belongs to the group of ANCA-associated necrotizing vasculitides. This study describes the clinical picture of the disease in a large cohort of GPA paediatric patients. Children with age at diagnosis {= 18 years, fulfilling the EULAR/PRINTO/PRES GPA/WG classification criteria were extracted from the PRINTO vasculitis database. The clinical signs/symptoms and laboratory features were analysed before or atthe time of diagnosis and at least 3 months thereafter and compared with other paediatric and adult case series (>50 patients) derived from the literature. Findings: The 56 children with GPA/WG were predominantly females (68%) and Caucasians (82%) witha median age at disease onset of 11.7 years, and a median delay in diagnosis of 4.2 months. The most frequent organ systems involved before/at the time of diagnosis were ears, nose, throat (91%), constitutional (malaise, fever, weight los

Název v anglickém jazyce

Clinical features of childhood granulomatosis with polyangiitis (wegener's granulomatosis)

Popis výsledku anglicky

Background: Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis (WG), belongs to the group of ANCA-associated necrotizing vasculitides. This study describes the clinical picture of the disease in a large cohort of GPA paediatric patients. Children with age at diagnosis {= 18 years, fulfilling the EULAR/PRINTO/PRES GPA/WG classification criteria were extracted from the PRINTO vasculitis database. The clinical signs/symptoms and laboratory features were analysed before or atthe time of diagnosis and at least 3 months thereafter and compared with other paediatric and adult case series (>50 patients) derived from the literature. Findings: The 56 children with GPA/WG were predominantly females (68%) and Caucasians (82%) witha median age at disease onset of 11.7 years, and a median delay in diagnosis of 4.2 months. The most frequent organ systems involved before/at the time of diagnosis were ears, nose, throat (91%), constitutional (malaise, fever, weight los

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FG - Pediatrie

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pediatric Rheumatology

ISSN

1546-0096

e-ISSN

—

Svazek periodika

12

Číslo periodika v rámci svazku

May

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

—

Kód UT WoS článku

000336749400001

EID výsledku v databázi Scopus

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