The effect of Vancomycin degradation products in the topical treatment of osteomyelitis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10286541" target="_blank" >RIV/00216208:11110/14:10286541 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/14:10286541 RIV/00064203:_____/14:10286541

Výsledek na webu

<a href="http://dx.doi.org/10.4149/BLL_2014_154" target="_blank" >http://dx.doi.org/10.4149/BLL_2014_154</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/BLL_2014_154" target="_blank" >10.4149/BLL_2014_154</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The effect of Vancomycin degradation products in the topical treatment of osteomyelitis

Popis výsledku v původním jazyce

The topical application of Vancomycin is increasingly being used in orthopedics because of the development of methicillin resistant bacteria. Consequently, resistance to Vancomycin has recently been on the rise. One possible explanation for this phenomenon could be the thermal degradation of Vancomycin to antibacterially inactive crystalline degradation products (CDP-1s).In our experiment in vitro the CDP-1s and the factor B (active form) released from bone grafts into the buffer solution were measuredusing the HPLC at progressive intervals. The CDP-1 levels kept increasing until the end of measurement on day 15, when the concentration of CDP-1s (1280.7 mg/L) was much higher compared to that of factor B (217.5 mg/L). We confirmed the tendency of Vancomycin to convert to antimicrobially ineffective CDP-1s. Although Vancomycin is decomposed into crystalline degradation products, its active forms are released from bone grafts in sufficient concentration for more than two weeks.

Název v anglickém jazyce

The effect of Vancomycin degradation products in the topical treatment of osteomyelitis

Popis výsledku anglicky

The topical application of Vancomycin is increasingly being used in orthopedics because of the development of methicillin resistant bacteria. Consequently, resistance to Vancomycin has recently been on the rise. One possible explanation for this phenomenon could be the thermal degradation of Vancomycin to antibacterially inactive crystalline degradation products (CDP-1s).In our experiment in vitro the CDP-1s and the factor B (active form) released from bone grafts into the buffer solution were measuredusing the HPLC at progressive intervals. The CDP-1 levels kept increasing until the end of measurement on day 15, when the concentration of CDP-1s (1280.7 mg/L) was much higher compared to that of factor B (217.5 mg/L). We confirmed the tendency of Vancomycin to convert to antimicrobially ineffective CDP-1s. Although Vancomycin is decomposed into crystalline degradation products, its active forms are released from bone grafts in sufficient concentration for more than two weeks.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FI - Traumatologie a ortopedie

OECD FORD obor

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Projekt

<a href="/cs/project/NT14218" target="_blank" >NT14218: Využití antimikrobiálních peptidů k léčbě infekcí pohybového ústrojí za pomoci lokálních nosičů užívaných v ortopedii</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bratislavské lekárske listy

ISSN

0006-9248

e-ISSN

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Svazek periodika

115

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

4

Strana od-do

796-799

Kód UT WoS článku

000348244100013

EID výsledku v databázi Scopus

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