Tolerability of the capsaicin 8% patch following pretreatment with lidocaine or tramadol in patients with peripheral neuropathic pain: A multicentre, randomized, assessor-blinded study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10286825" target="_blank" >RIV/00216208:11110/14:10286825 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/14:10286825

Výsledek na webu

<a href="http://dx.doi.org/10.1002/j.1532-2149.2014.00479.x" target="_blank" >http://dx.doi.org/10.1002/j.1532-2149.2014.00479.x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/j.1532-2149.2014.00479.x" target="_blank" >10.1002/j.1532-2149.2014.00479.x</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Tolerability of the capsaicin 8% patch following pretreatment with lidocaine or tramadol in patients with peripheral neuropathic pain: A multicentre, randomized, assessor-blinded study

Popis výsledku v původním jazyce

BackgroundApplication of the capsaicin 8% patch is associated with treatment-related discomfort. Consequently, pretreatment for 60min with anaesthetic cream is recommended; however, this may be uncomfortable and time consuming. MethodsWe conducted a multicentre, randomized (1:1), assessor-blinded study in patients with peripheral neuropathic pain to assess tolerability of the capsaicin patch following topical lidocaine (4%) or oral tramadol (50mg) pretreatment. The primary endpoint was the proportion ofpatients tolerating capsaicin patch application (ability to receive 90% of a 60-min application). Numeric Pain Rating Scale (NPRS) scores were assessed before, during and after treatment. ResultsOverall, 122 patients were included (61 per arm). The capsaicin patch was tolerated by 121 patients. Tolerability of the capsaicin patch was similar following pretreatment with lidocaine and tramadol. Following patch application, pain levels increased up to 55min (change from baseline of 1.3 for

Název v anglickém jazyce

Tolerability of the capsaicin 8% patch following pretreatment with lidocaine or tramadol in patients with peripheral neuropathic pain: A multicentre, randomized, assessor-blinded study

Popis výsledku anglicky

BackgroundApplication of the capsaicin 8% patch is associated with treatment-related discomfort. Consequently, pretreatment for 60min with anaesthetic cream is recommended; however, this may be uncomfortable and time consuming. MethodsWe conducted a multicentre, randomized (1:1), assessor-blinded study in patients with peripheral neuropathic pain to assess tolerability of the capsaicin patch following topical lidocaine (4%) or oral tramadol (50mg) pretreatment. The primary endpoint was the proportion ofpatients tolerating capsaicin patch application (ability to receive 90% of a 60-min application). Numeric Pain Rating Scale (NPRS) scores were assessed before, during and after treatment. ResultsOverall, 122 patients were included (61 per arm). The capsaicin patch was tolerated by 121 patients. Tolerability of the capsaicin patch was similar following pretreatment with lidocaine and tramadol. Following patch application, pain levels increased up to 55min (change from baseline of 1.3 for

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Pain

ISSN

1090-3801

e-ISSN

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Svazek periodika

18

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

1240-1247

Kód UT WoS článku

000341979800005

EID výsledku v databázi Scopus

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