Low levels of circulating T-regulatory lymphocytes and short cervical length are associated with preterm labor

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10287133" target="_blank" >RIV/00216208:11110/14:10287133 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/14:10287133

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jri.2014.04.001" target="_blank" >http://dx.doi.org/10.1016/j.jri.2014.04.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jri.2014.04.001" target="_blank" >10.1016/j.jri.2014.04.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Low levels of circulating T-regulatory lymphocytes and short cervical length are associated with preterm labor

Popis výsledku v původním jazyce

Recent discoveries suggest that T-regulatory lymphocytes (Treg) might play an important role in the pathophysiology of preterm labor. The aim of this study was to assess the relationship among the levels of maternal circulating Treg cells, uterine cervical length, and the risk of preterm labor. Sixty women with regular contractions and/or cervical incompetence at 24-32 weeks' gestation were recruited into a prospective study. Each patient underwent transvaginal ultrasound examination of the cervical length, and regulatory T cells were quantified in peripheral blood samples by flow cytometry. Patients with cervical incompetence were prescribed vaginal progesterone until birth. Measurements of Treg levels and cervical length correlated with the timing oflabor. The risk of preterm labor happening within 48 h of testing was demonstrated to be almost 35 times higher (OR= 35.21, CI 13.3; 214, p < 0.001) in the group with simultaneously low Treg values (<0.031 x 10(9)/L) and a shortened uter

Název v anglickém jazyce

Low levels of circulating T-regulatory lymphocytes and short cervical length are associated with preterm labor

Popis výsledku anglicky

Recent discoveries suggest that T-regulatory lymphocytes (Treg) might play an important role in the pathophysiology of preterm labor. The aim of this study was to assess the relationship among the levels of maternal circulating Treg cells, uterine cervical length, and the risk of preterm labor. Sixty women with regular contractions and/or cervical incompetence at 24-32 weeks' gestation were recruited into a prospective study. Each patient underwent transvaginal ultrasound examination of the cervical length, and regulatory T cells were quantified in peripheral blood samples by flow cytometry. Patients with cervical incompetence were prescribed vaginal progesterone until birth. Measurements of Treg levels and cervical length correlated with the timing oflabor. The risk of preterm labor happening within 48 h of testing was demonstrated to be almost 35 times higher (OR= 35.21, CI 13.3; 214, p < 0.001) in the group with simultaneously low Treg values (<0.031 x 10(9)/L) and a shortened uter

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Reproductive Immunology

ISSN

0165-0378

e-ISSN

—

Svazek periodika

106

Číslo periodika v rámci svazku

neuvedeno

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

110-117

Kód UT WoS článku

000345948700061

EID výsledku v databázi Scopus

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