Inflammatory myopathy associated with statins: report of three cases

Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10289106" target="_blank" >RIV/00216208:11110/14:10289106 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11130/14:10289106 RIV/00064203:_____/14:10289106 RIV/00023728:_____/14:#0004042 RIV/00064190:_____/14:#0000960 RIV/00064165:_____/14:10289106
Výsledek na webu
<a href="http://dx.doi.org/10.3109/14397595.2013.852848" target="_blank" >http://dx.doi.org/10.3109/14397595.2013.852848</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/14397595.2013.852848" target="_blank" >10.3109/14397595.2013.852848</a>

Jazyk výsledku
angličtina
Název v původním jazyce
Inflammatory myopathy associated with statins: report of three cases
Popis výsledku v původním jazyce
Statins are well-established lipid-lowering drugs that reduce morbidity and mortality due to cardiovascular disease and cause adverse effects relatively rarely. It is still unclear whether statins are capable of inducing an immune-mediated response directed against skeletal muscle. Here, we present the cases of three patients who developed inflammatory myopathy in the course of statin treatment. Moreover, multiple mitochondrial DNA deletions were found in two of them. The ability of statins to induce animmune-mediated response and their interactions with mitochondrial metabolism pathways are discussed.
Název v anglickém jazyce
Inflammatory myopathy associated with statins: report of three cases
Popis výsledku anglicky
Statins are well-established lipid-lowering drugs that reduce morbidity and mortality due to cardiovascular disease and cause adverse effects relatively rarely. It is still unclear whether statins are capable of inducing an immune-mediated response directed against skeletal muscle. Here, we present the cases of three patients who developed inflammatory myopathy in the course of statin treatment. Moreover, multiple mitochondrial DNA deletions were found in two of them. The ability of statins to induce animmune-mediated response and their interactions with mitochondrial metabolism pathways are discussed.

Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FE - Ostatní obory vnitřního lékařství
OECD FORD obor
—

Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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