Focused tandem shock waves in water and their potential application in cancer treatment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10290555" target="_blank" >RIV/00216208:11110/14:10290555 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389021:_____/14:00423247

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00193-013-0462-7" target="_blank" >http://dx.doi.org/10.1007/s00193-013-0462-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00193-013-0462-7" target="_blank" >10.1007/s00193-013-0462-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Focused tandem shock waves in water and their potential application in cancer treatment

Popis výsledku v původním jazyce

The generator of two focused successive (tandem) shock waves (FTSW) in water produced by underwater multichannel electrical discharges at two composite electrodes, with a time delay between the first and second shock waves of 10 mu s, was developed. It produces, at the focus, a strong shock wave with a peak positive pressure of up to 80 MPa, followed by a tensile wave with a peak negative pressure of up to -80 MPa, thus generating at the focus a large amount of cavitation. Biological effects of FTSW were demonstrated in vitro on hemolysis of erythrocytes and cell viability of human acute lymphoblastic leukemia cells as well as on tumor growth delay ex vivo and in vivo experiments performed with B16 melanoma, T-lymphoma, and R5-28 sarcoma cell lines. Itwas demonstrated in vivo that FTSW can enhance antitumor effects of chemotherapeutic drugs, such as cisplatin, most likely due to increased permeability of the membrane of cancer cells induced by FTSW. Synergetic cytotoxicity of FTSW wit

Název v anglickém jazyce

Focused tandem shock waves in water and their potential application in cancer treatment

Popis výsledku anglicky

The generator of two focused successive (tandem) shock waves (FTSW) in water produced by underwater multichannel electrical discharges at two composite electrodes, with a time delay between the first and second shock waves of 10 mu s, was developed. It produces, at the focus, a strong shock wave with a peak positive pressure of up to 80 MPa, followed by a tensile wave with a peak negative pressure of up to -80 MPa, thus generating at the focus a large amount of cavitation. Biological effects of FTSW were demonstrated in vitro on hemolysis of erythrocytes and cell viability of human acute lymphoblastic leukemia cells as well as on tumor growth delay ex vivo and in vivo experiments performed with B16 melanoma, T-lymphoma, and R5-28 sarcoma cell lines. Itwas demonstrated in vivo that FTSW can enhance antitumor effects of chemotherapeutic drugs, such as cisplatin, most likely due to increased permeability of the membrane of cancer cells induced by FTSW. Synergetic cytotoxicity of FTSW wit

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/GA202%2F09%2F1151" target="_blank" >GA202/09/1151: Dvě po sobě následující fokusované rázové vlny a jejich potenciální využití v terapii nádorů a řízeném uvolňování léčiv</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Shock Waves

ISSN

0938-1287

e-ISSN

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Svazek periodika

24

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

7

Strana od-do

51-57

Kód UT WoS článku

000331656400007

EID výsledku v databázi Scopus

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