Microbiome and Colorectal Carcinoma Insights From Germ-Free and Conventional Animal Models

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10292189" target="_blank" >RIV/00216208:11110/14:10292189 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388971:_____/14:00435686

Výsledek na webu

<a href="http://dx.doi.org/10.1097/PPO.0000000000000052" target="_blank" >http://dx.doi.org/10.1097/PPO.0000000000000052</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/PPO.0000000000000052" target="_blank" >10.1097/PPO.0000000000000052</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Microbiome and Colorectal Carcinoma Insights From Germ-Free and Conventional Animal Models

Popis výsledku v původním jazyce

The mammalian microbiota plays a crucial role in the pathogenesis of many diseases. Thanks to recent advances in metagenomics, proteomics, and metabolomics, microbiome composition and metabolic activity can now be studied in detail. Results obtained by such fascinating and provocative studies would be meaningless without considering the perspective of the whole organism. Our work using gnotobiology as the major tool to unravel the mechanisms of host-microbe interaction has demonstrated the crucial roleof microbiota in the initiation and progression of inflammation-associated colorectal neoplasia. Carcinogenesis in the gut is driven by the presence of potentially harmful microbes or by lack of protective ones, by the production of carcinogens generatedby microbes, and by the induction of inflammation and modulation of the immune system. Here, we review these mechanisms with special emphasis on those where gnotobiology has yielded important insights.

Název v anglickém jazyce

Microbiome and Colorectal Carcinoma Insights From Germ-Free and Conventional Animal Models

Popis výsledku anglicky

The mammalian microbiota plays a crucial role in the pathogenesis of many diseases. Thanks to recent advances in metagenomics, proteomics, and metabolomics, microbiome composition and metabolic activity can now be studied in detail. Results obtained by such fascinating and provocative studies would be meaningless without considering the perspective of the whole organism. Our work using gnotobiology as the major tool to unravel the mechanisms of host-microbe interaction has demonstrated the crucial roleof microbiota in the initiation and progression of inflammation-associated colorectal neoplasia. Carcinogenesis in the gut is driven by the presence of potentially harmful microbes or by lack of protective ones, by the production of carcinogens generatedby microbes, and by the induction of inflammation and modulation of the immune system. Here, we review these mechanisms with special emphasis on those where gnotobiology has yielded important insights.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cancer Journal

ISSN

1528-9117

e-ISSN

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Svazek periodika

20

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

217-224

Kód UT WoS článku

000337708000010

EID výsledku v databázi Scopus

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