Cortical and Subcortical Atrophy in Alzheimer Disease Parallel Atrophy of Thalamus and Hippocampus

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10292720" target="_blank" >RIV/00216208:11110/14:10292720 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/14:00060931 RIV/00216208:11130/14:10292720 RIV/00064203:_____/14:10292720

Výsledek na webu

<a href="http://dx.doi.org/10.1097/WAD.0b013e318299d3d6" target="_blank" >http://dx.doi.org/10.1097/WAD.0b013e318299d3d6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/WAD.0b013e318299d3d6" target="_blank" >10.1097/WAD.0b013e318299d3d6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cortical and Subcortical Atrophy in Alzheimer Disease Parallel Atrophy of Thalamus and Hippocampus

Popis výsledku v původním jazyce

Brain atrophy is a key imaging hallmark of Alzheimer disease (AD). In this study, we carried out an integrative evaluation of AD-related atrophy. Twelve patients with AD and 13 healthy controls were enrolled. We conducted a cross-sectional analysis of total brain tissue volumes with SIENAX. Localized gray matter atrophy was identified with optimized voxel-wise morphometry (FSL-VBM), and subcortical atrophy was evaluated by active shape model implemented in FMRIB's Integrated Registration Segmentation Toolkit. SIENAX analysis demonstrated total brain atrophy in AD patients; voxel-based morphometry analysis showed atrophy in the bilateral mediotemporal regions and in the posterior brain regions. In addition, regarding the diminished volumes of thalami and hippocampi in AD patients, subsequent vertex analysis of the segmented structures indicated shrinkage of the bilateral anterior thalami and the left medial hippocampus. Interestingly, the volume of the thalami and hippocampi were highly

Název v anglickém jazyce

Cortical and Subcortical Atrophy in Alzheimer Disease Parallel Atrophy of Thalamus and Hippocampus

Popis výsledku anglicky

Brain atrophy is a key imaging hallmark of Alzheimer disease (AD). In this study, we carried out an integrative evaluation of AD-related atrophy. Twelve patients with AD and 13 healthy controls were enrolled. We conducted a cross-sectional analysis of total brain tissue volumes with SIENAX. Localized gray matter atrophy was identified with optimized voxel-wise morphometry (FSL-VBM), and subcortical atrophy was evaluated by active shape model implemented in FMRIB's Integrated Registration Segmentation Toolkit. SIENAX analysis demonstrated total brain atrophy in AD patients; voxel-based morphometry analysis showed atrophy in the bilateral mediotemporal regions and in the posterior brain regions. In addition, regarding the diminished volumes of thalami and hippocampi in AD patients, subsequent vertex analysis of the segmented structures indicated shrinkage of the bilateral anterior thalami and the left medial hippocampus. Interestingly, the volume of the thalami and hippocampi were highly

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Alzheimer Disease and Associated Disorders

ISSN

0893-0341

e-ISSN

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Svazek periodika

28

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

65-72

Kód UT WoS článku

000332086700010

EID výsledku v databázi Scopus

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