Changes in activity of metabolic and regulatory pathways during germination of S-coelicolor

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10293640" target="_blank" >RIV/00216208:11110/14:10293640 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388971:_____/14:00439959 RIV/44555601:13440/14:43886277 RIV/61388971:_____/14:00506585

Výsledek na webu

<a href="http://dx.doi.org/10.1186/1471-2164-15-1173" target="_blank" >http://dx.doi.org/10.1186/1471-2164-15-1173</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1471-2164-15-1173" target="_blank" >10.1186/1471-2164-15-1173</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Changes in activity of metabolic and regulatory pathways during germination of S-coelicolor

Popis výsledku v původním jazyce

Background: Bacterial spore germination is a developmental process during which all required metabolic pathways are restored to transfer cells from their dormant state into vegetative growth. Streptomyces are soil dwelling filamentous bacteria with complex life cycle, studied mostly for they ability to synthesize secondary metabolites including antibiotics. Results: Here, we present a systematic approach that analyzes gene expression data obtained from 13 time points taken over 5.5 h of Streptomyces germination. Genes whose expression was significantly enhanced/diminished during the time-course were identified, and classified to metabolic and regulatory pathways. The classification into metabolic pathways revealed timing of the activation of specific pathways during the course of germination. The analysis also identified remarkable changes in the expression of specific sigma factors over the course of germination. Based on our knowledge of the targets of these factors, we speculate on

Název v anglickém jazyce

Changes in activity of metabolic and regulatory pathways during germination of S-coelicolor

Popis výsledku anglicky

Background: Bacterial spore germination is a developmental process during which all required metabolic pathways are restored to transfer cells from their dormant state into vegetative growth. Streptomyces are soil dwelling filamentous bacteria with complex life cycle, studied mostly for they ability to synthesize secondary metabolites including antibiotics. Results: Here, we present a systematic approach that analyzes gene expression data obtained from 13 time points taken over 5.5 h of Streptomyces germination. Genes whose expression was significantly enhanced/diminished during the time-course were identified, and classified to metabolic and regulatory pathways. The classification into metabolic pathways revealed timing of the activation of specific pathways during the course of germination. The analysis also identified remarkable changes in the expression of specific sigma factors over the course of germination. Based on our knowledge of the targets of these factors, we speculate on

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BMC Genomics

ISSN

1471-2164

e-ISSN

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Svazek periodika

15

Číslo periodika v rámci svazku

december

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

15

Strana od-do

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Kód UT WoS článku

000347731600001

EID výsledku v databázi Scopus

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