Rare Alleles within the CYP2E1 (MEOS System) Could be Associated with Better Short-Term Health Outcome after Acute Methanol Poisoning

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10282057" target="_blank" >RIV/00216208:11110/15:10282057 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/15:00059246 RIV/00064165:_____/15:10282057

Výsledek na webu

<a href="http://dx.doi.org/10.1111/bcpt.12310" target="_blank" >http://dx.doi.org/10.1111/bcpt.12310</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/bcpt.12310" target="_blank" >10.1111/bcpt.12310</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Rare Alleles within the CYP2E1 (MEOS System) Could be Associated with Better Short-Term Health Outcome after Acute Methanol Poisoning

Popis výsledku v původním jazyce

Genetic polymorphisms influence the metabolism of ethanol and methanol, but the potential effects of genetic predisposition on the clinical course, outcome and short-term health sequelae of acute methanol poisoning are unknown. To evaluate the role of the MEOS system in methanol poisoning, we analysed the effect of three polymorphisms (RsaI - rs2031920; PstI - rs3813867; insertion/deletion I/D) within the CYP2E1 enzyme (MEOS system) in 50 adult survivors of methanol poisoning and compared their genotypefrequencies with 460 controls. The minor allele frequencies of all three polymorphisms were below 5% in both groups. We did not detect significant differences in the genotype frequencies between survivors of methanol poisoning and controls (p=0.34 for the RsaI variant; p=0.59 for the PstI variant and p=0.21 for the I/D polymorphism). The carriers of at least one minor allele in the CYP2E1 gene had less severe clinical symptoms and better short-term outcome after acute poisoning. Variant

Název v anglickém jazyce

Rare Alleles within the CYP2E1 (MEOS System) Could be Associated with Better Short-Term Health Outcome after Acute Methanol Poisoning

Popis výsledku anglicky

Genetic polymorphisms influence the metabolism of ethanol and methanol, but the potential effects of genetic predisposition on the clinical course, outcome and short-term health sequelae of acute methanol poisoning are unknown. To evaluate the role of the MEOS system in methanol poisoning, we analysed the effect of three polymorphisms (RsaI - rs2031920; PstI - rs3813867; insertion/deletion I/D) within the CYP2E1 enzyme (MEOS system) in 50 adult survivors of methanol poisoning and compared their genotypefrequencies with 460 controls. The minor allele frequencies of all three polymorphisms were below 5% in both groups. We did not detect significant differences in the genotype frequencies between survivors of methanol poisoning and controls (p=0.34 for the RsaI variant; p=0.59 for the PstI variant and p=0.21 for the I/D polymorphism). The carriers of at least one minor allele in the CYP2E1 gene had less severe clinical symptoms and better short-term outcome after acute poisoning. Variant

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Basic and Clinical Pharmacology and Toxicology

ISSN

1742-7835

e-ISSN

—

Svazek periodika

116

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

DK - Dánské království

Počet stran výsledku

5

Strana od-do

168-172

Kód UT WoS článku

000348497700012

EID výsledku v databázi Scopus

2-s2.0-84921279364