Characterization of a new human plasma cell leukemia cell line UHKT-944

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10289268" target="_blank" >RIV/00216208:11110/15:10289268 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/15:10289268 RIV/00216208:11210/15:10289268 RIV/00023736:_____/15:00011283 RIV/00064165:_____/15:10289268

Výsledek na webu

<a href="http://dx.doi.org/10.1111/ejh.12505" target="_blank" >http://dx.doi.org/10.1111/ejh.12505</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/ejh.12505" target="_blank" >10.1111/ejh.12505</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Characterization of a new human plasma cell leukemia cell line UHKT-944

Popis výsledku v původním jazyce

A new interleukin-6 (IL-6)-dependent plasma cell leukemia cell line UHKT-944 was established from bone marrow cells derived from a 55-yr-old man with plasma cell leukemia. The cell line possesses phenotypic characteristics of plasma cells including the production of a monoclonal immunoglobulin IgA1-kappa. VH3-9 region of IgVH genes was rearranged and somatically hypermutated. The UHKT-944 cells were found to be negative for most of tested B-cell, T-cell, and myeloid markers. According to cytogenetic analysis, the cells were classified as near tetraploid with several numerical and structural abnormalities including the t(14;20) involving IgH locus. The established permanent plasma cell leukemia cell line is a suitable model for the study of cellular andmolecular mechanisms of pathogenesis of this rare malignant disease.

Název v anglickém jazyce

Characterization of a new human plasma cell leukemia cell line UHKT-944

Popis výsledku anglicky

A new interleukin-6 (IL-6)-dependent plasma cell leukemia cell line UHKT-944 was established from bone marrow cells derived from a 55-yr-old man with plasma cell leukemia. The cell line possesses phenotypic characteristics of plasma cells including the production of a monoclonal immunoglobulin IgA1-kappa. VH3-9 region of IgVH genes was rearranged and somatically hypermutated. The UHKT-944 cells were found to be negative for most of tested B-cell, T-cell, and myeloid markers. According to cytogenetic analysis, the cells were classified as near tetraploid with several numerical and structural abnormalities including the t(14;20) involving IgH locus. The established permanent plasma cell leukemia cell line is a suitable model for the study of cellular andmolecular mechanisms of pathogenesis of this rare malignant disease.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

—

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Haematology

ISSN

0902-4441

e-ISSN

—

Svazek periodika

95

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

DK - Dánské království

Počet stran výsledku

9

Strana od-do

352-360

Kód UT WoS článku

000361489700011

EID výsledku v databázi Scopus

2-s2.0-84941260848