The harmful chemistry behind krokodil (desomorphine) synthesis and mechanisms of toxicity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10294938" target="_blank" >RIV/00216208:11110/15:10294938 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.forsciint.2015.02.001" target="_blank" >http://dx.doi.org/10.1016/j.forsciint.2015.02.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.forsciint.2015.02.001" target="_blank" >10.1016/j.forsciint.2015.02.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The harmful chemistry behind krokodil (desomorphine) synthesis and mechanisms of toxicity

Popis výsledku v původním jazyce

"Krokodil'' is the street name for the homemade injectable mixture that has been used as a cheap substitute for heroin. Its use begun in Russia and Ukraine and nowadays is being spread over several other countries. Desomorphine is the semi-synthetic opioid claimed to be the main component of krokodil and considered to be responsible for its psychoactive characteristics. The starting materials for desomorphine synthesis are codeine tablets, alkali solutions, organic solvent, acidified water, iodine and red phosphorus, all of which are easily available in retail outlets, such as supermarkets, drugstores, etc. The resulting product is a light brown liquid that is called krokodil. People who inject krokodil present a great variety of serious signs and symptoms, including thrombophlebitis, ulcerations, gangrene, and necrosis, quickly evolving to limb amputation and death. These effects are thought to result from the toxic components produced as byproducts during the homemade drug synthesis.

Název v anglickém jazyce

The harmful chemistry behind krokodil (desomorphine) synthesis and mechanisms of toxicity

Popis výsledku anglicky

"Krokodil'' is the street name for the homemade injectable mixture that has been used as a cheap substitute for heroin. Its use begun in Russia and Ukraine and nowadays is being spread over several other countries. Desomorphine is the semi-synthetic opioid claimed to be the main component of krokodil and considered to be responsible for its psychoactive characteristics. The starting materials for desomorphine synthesis are codeine tablets, alkali solutions, organic solvent, acidified water, iodine and red phosphorus, all of which are easily available in retail outlets, such as supermarkets, drugstores, etc. The resulting product is a light brown liquid that is called krokodil. People who inject krokodil present a great variety of serious signs and symptoms, including thrombophlebitis, ulcerations, gangrene, and necrosis, quickly evolving to limb amputation and death. These effects are thought to result from the toxic components produced as byproducts during the homemade drug synthesis.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Forensic Science International

ISSN

0379-0738

e-ISSN

—

Svazek periodika

249

Číslo periodika v rámci svazku

April

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

7

Strana od-do

207-213

Kód UT WoS článku

000351947300035

EID výsledku v databázi Scopus

2-s2.0-84923282607