Is copper imbalance an environmental factor influencing keratoconus development?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10294994" target="_blank" >RIV/00216208:11110/15:10294994 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/15:10294994

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.mehy.2015.02.017" target="_blank" >http://dx.doi.org/10.1016/j.mehy.2015.02.017</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.mehy.2015.02.017" target="_blank" >10.1016/j.mehy.2015.02.017</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Is copper imbalance an environmental factor influencing keratoconus development?

Popis výsledku v původním jazyce

Keratoconus is a bilateral disease characterized by progressive corneal thinning leading to irregular astigmatism that results in significant visual impairment. Despite extensive research, the exact etiopathogenesis of keratoconus remains unknown. Many copper-dependent enzymes such as superoxide dismutases, cytochrome c oxidase and lysyl oxidase have been shown to be altered in keratoconic corneas, and a decrease of copper levels in the diseased tissue has been reported as well. We propose a hypothesislinking all the putative pathways of keratoconus development and suggest that copper imbalance in corneal tissue may be an independent risk factor for the disease. The assessment of copper levels and its distribution in keratoconic corneas warrants further investigation.

Název v anglickém jazyce

Is copper imbalance an environmental factor influencing keratoconus development?

Popis výsledku anglicky

Keratoconus is a bilateral disease characterized by progressive corneal thinning leading to irregular astigmatism that results in significant visual impairment. Despite extensive research, the exact etiopathogenesis of keratoconus remains unknown. Many copper-dependent enzymes such as superoxide dismutases, cytochrome c oxidase and lysyl oxidase have been shown to be altered in keratoconic corneas, and a decrease of copper levels in the diseased tissue has been reported as well. We propose a hypothesislinking all the putative pathways of keratoconus development and suggest that copper imbalance in corneal tissue may be an independent risk factor for the disease. The assessment of copper levels and its distribution in keratoconic corneas warrants further investigation.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

—

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Medical Hypotheses

ISSN

0306-9877

e-ISSN

—

Svazek periodika

84

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

518-524

Kód UT WoS článku

000352672900025

EID výsledku v databázi Scopus

2-s2.0-84925834665