Risk Factors for Neurodegeneration in Idiopathic Rapid Eye Movement Sleep Behavior Disorder: A Multicenter Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295087" target="_blank" >RIV/00216208:11110/15:10295087 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/15:10295087

Výsledek na webu

<a href="http://dx.doi.org/10.1002/ana.24385" target="_blank" >http://dx.doi.org/10.1002/ana.24385</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ana.24385" target="_blank" >10.1002/ana.24385</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Risk Factors for Neurodegeneration in Idiopathic Rapid Eye Movement Sleep Behavior Disorder: A Multicenter Study

Popis výsledku v původním jazyce

ObjectiveTo assess whether risk factors for Parkinson disease and dementia with Lewy bodies increase rate of defined neurodegenerative disease in idiopathic rapid eye movement (REM) sleep behavior disorder (RBD). MethodsTwelve centers administered a detailed questionnaire assessing risk factors for neurodegenerative synucleinopathy to patients with idiopathic RBD. Variables included demographics, lifestyle factors, pesticide exposures, occupation, comorbid conditions, medication use, family history, andautonomic/motor symptoms. After 4 years of follow-up, patients were assessed for dementia or parkinsonism. Disease risk was assessed with Kaplan-Meier analysis, and epidemiologic variables were compared between convertors and those still idiopathic using logistic regression. ResultsOf 305 patients, follow-up information was available for 279, of whom 93 (33.3%) developed defined neurodegenerative disease. Disease risk was 25% at 3 years and 41% after 5 years. Patients who converted were

Název v anglickém jazyce

Risk Factors for Neurodegeneration in Idiopathic Rapid Eye Movement Sleep Behavior Disorder: A Multicenter Study

Popis výsledku anglicky

ObjectiveTo assess whether risk factors for Parkinson disease and dementia with Lewy bodies increase rate of defined neurodegenerative disease in idiopathic rapid eye movement (REM) sleep behavior disorder (RBD). MethodsTwelve centers administered a detailed questionnaire assessing risk factors for neurodegenerative synucleinopathy to patients with idiopathic RBD. Variables included demographics, lifestyle factors, pesticide exposures, occupation, comorbid conditions, medication use, family history, andautonomic/motor symptoms. After 4 years of follow-up, patients were assessed for dementia or parkinsonism. Disease risk was assessed with Kaplan-Meier analysis, and epidemiologic variables were compared between convertors and those still idiopathic using logistic regression. ResultsOf 305 patients, follow-up information was available for 279, of whom 93 (33.3%) developed defined neurodegenerative disease. Disease risk was 25% at 3 years and 41% after 5 years. Patients who converted were

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Annals of Neurology

ISSN

0364-5134

e-ISSN

—

Svazek periodika

77

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

830-839

Kód UT WoS článku

000353235400011

EID výsledku v databázi Scopus

2-s2.0-84928215818